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A novel process design for automated quality analysis in an integrated biopharmaceutical platform

Tallvod, Simon LU ; Yamanee-Nolin, Mikael LU ; Gomis-Fons, Joaqúın LU ; Andersson, Niklas LU orcid and Nilsson, Bernt LU orcid (2022) In Computer Aided Chemical Engineering 51. p.619-624
Abstract

This contribution describes a novel process design consisting of the implementation of a high performance liquid chromatography (HPLC) system into an existing integrated biopharmaceutical purification platform in order to extend the possibilities of analysis. This setup is controlled by a custom-made set of software tools, namely the combination of Orbit along with a C# based program called Satellite, which is used to link the HPLC system to Orbit. By using this process design, automated analysis of the continuous process flow is made possible, generating full wavelength spectra, and automated pool quality analysis. These spectra contain at least an order of magnitude more data compared to a standard chromatogram, which can be utilized... (More)

This contribution describes a novel process design consisting of the implementation of a high performance liquid chromatography (HPLC) system into an existing integrated biopharmaceutical purification platform in order to extend the possibilities of analysis. This setup is controlled by a custom-made set of software tools, namely the combination of Orbit along with a C# based program called Satellite, which is used to link the HPLC system to Orbit. By using this process design, automated analysis of the continuous process flow is made possible, generating full wavelength spectra, and automated pool quality analysis. These spectra contain at least an order of magnitude more data compared to a standard chromatogram, which can be utilized for further analysis, while the pool quality analyses can be used for making decisions regarding how to proceed with a particular pool. The results of the study show the successful implementation of automated analytic tools to the purification process, which also indicates that the process carries promise as a generalizable platform for Orbit-controlled designs for different analysis purposes.

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author
; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
automated analysis, chromatographic purification, integrated downstream processing, novel process design
host publication
32nd European Symposium on Computer Aided Process Engineering
series title
Computer Aided Chemical Engineering
volume
51
pages
6 pages
publisher
Elsevier Science Publishers B.V.
external identifiers
  • scopus:85135363608
ISSN
1570-7946
ISBN
978-0-323-95879-0
DOI
10.1016/B978-0-323-95879-0.50104-1
language
English
LU publication?
yes
id
447bc07a-f4d7-49c5-b74f-c978f411de84
date added to LUP
2022-09-20 14:33:19
date last changed
2024-11-29 15:33:31
@inbook{447bc07a-f4d7-49c5-b74f-c978f411de84,
  abstract     = {{<p>This contribution describes a novel process design consisting of the implementation of a high performance liquid chromatography (HPLC) system into an existing integrated biopharmaceutical purification platform in order to extend the possibilities of analysis. This setup is controlled by a custom-made set of software tools, namely the combination of Orbit along with a C# based program called Satellite, which is used to link the HPLC system to Orbit. By using this process design, automated analysis of the continuous process flow is made possible, generating full wavelength spectra, and automated pool quality analysis. These spectra contain at least an order of magnitude more data compared to a standard chromatogram, which can be utilized for further analysis, while the pool quality analyses can be used for making decisions regarding how to proceed with a particular pool. The results of the study show the successful implementation of automated analytic tools to the purification process, which also indicates that the process carries promise as a generalizable platform for Orbit-controlled designs for different analysis purposes.</p>}},
  author       = {{Tallvod, Simon and Yamanee-Nolin, Mikael and Gomis-Fons, Joaqúın and Andersson, Niklas and Nilsson, Bernt}},
  booktitle    = {{32nd European Symposium on Computer Aided Process Engineering}},
  isbn         = {{978-0-323-95879-0}},
  issn         = {{1570-7946}},
  keywords     = {{automated analysis; chromatographic purification; integrated downstream processing; novel process design}},
  language     = {{eng}},
  pages        = {{619--624}},
  publisher    = {{Elsevier Science Publishers B.V.}},
  series       = {{Computer Aided Chemical Engineering}},
  title        = {{A novel process design for automated quality analysis in an integrated biopharmaceutical platform}},
  url          = {{http://dx.doi.org/10.1016/B978-0-323-95879-0.50104-1}},
  doi          = {{10.1016/B978-0-323-95879-0.50104-1}},
  volume       = {{51}},
  year         = {{2022}},
}