Tools for digital twins in continuous downstream processing
(2023)- Abstract
- Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.
This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling,... (More) - Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.
This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/191aa4b8-990d-47f1-a248-68bfb57ff330
- author
- Tallvod, Simon LU
- supervisor
- opponent
-
- Priv.-Doz. Dipl.-Ing. Dr. Dürauer, Astrid, University of Natural Resources and Life Sciences (BOKU), Austria
- organization
- publishing date
- 2023-11-24
- type
- Thesis
- publication status
- published
- subject
- keywords
- Digital twins, Biopharmaceuticals, Downstream processing, Chromatography, Mathematical modeling, Ion exchange, Automation, Sampling, Model calibration, Python
- pages
- 130 pages
- publisher
- Department of Chemical Engineering, Lund University
- defense location
- Lecture Hall DC:Stora hörsalen, IKDC, Sölvegatan 26, Faculty of Engineering LTH, Lund University, Lund
- defense date
- 2023-11-24 09:00:00
- ISBN
- 978-91-7422-996-7
- 978-91-7422-997-4
- language
- English
- LU publication?
- yes
- id
- 191aa4b8-990d-47f1-a248-68bfb57ff330
- date added to LUP
- 2023-10-18 14:24:01
- date last changed
- 2023-11-01 08:10:57
@phdthesis{191aa4b8-990d-47f1-a248-68bfb57ff330, abstract = {{Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.<br/>This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins.}}, author = {{Tallvod, Simon}}, isbn = {{978-91-7422-996-7}}, keywords = {{Digital twins; Biopharmaceuticals; Downstream processing; Chromatography; Mathematical modeling; Ion exchange; Automation; Sampling; Model calibration; Python}}, language = {{eng}}, month = {{11}}, publisher = {{Department of Chemical Engineering, Lund University}}, school = {{Lund University}}, title = {{Tools for digital twins in continuous downstream processing}}, url = {{https://lup.lub.lu.se/search/files/162287860/Simon_Tallvod_WEBB.pdf}}, year = {{2023}}, }