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Tools for digital twins in continuous downstream processing

Tallvod, Simon LU (2023)
Abstract
Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.
This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling,... (More)
Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.
This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins. (Less)
Please use this url to cite or link to this publication:
author
supervisor
opponent
  • Priv.-Doz. Dipl.-Ing. Dr. Dürauer, Astrid, University of Natural Resources and Life Sciences (BOKU), Austria
organization
publishing date
type
Thesis
publication status
published
subject
keywords
Digital twins, Biopharmaceuticals, Downstream processing, Chromatography, Mathematical modeling, Ion exchange, Automation, Sampling, Model calibration, Python
pages
130 pages
publisher
Department of Chemical Engineering, Lund University
defense location
Lecture Hall DC:Stora hörsalen, IKDC, Sölvegatan 26, Faculty of Engineering LTH, Lund University, Lund
defense date
2023-11-24 09:00:00
ISBN
978-91-7422-996-7
978-91-7422-997-4
language
English
LU publication?
yes
id
191aa4b8-990d-47f1-a248-68bfb57ff330
date added to LUP
2023-10-18 14:24:01
date last changed
2023-11-01 08:10:57
@phdthesis{191aa4b8-990d-47f1-a248-68bfb57ff330,
  abstract     = {{Biopharmaceuticals are of ever-growing importance for human health. The development and production of biopharmaceuticals has the potential for efficiency improvements by switching from batch-wise to continuous production. This change demands more advanced process control in the form of automation and digital tools such as digital twins, which in turn need adequate mathematical models and accessible process data.<br/>This thesis discusses the concept of digital twins as well as the automation of modelling and data acquisition in integrated continuous downstream processes for the development and production of biopharmaceuticals. Utilizing in-house supervisory control software for chromatographic systems enables automation of modeling, calibration, sampling, and analysis in integrated downstream processes, advancing the development of digital twins.}},
  author       = {{Tallvod, Simon}},
  isbn         = {{978-91-7422-996-7}},
  keywords     = {{Digital twins; Biopharmaceuticals; Downstream processing; Chromatography; Mathematical modeling; Ion exchange; Automation; Sampling; Model calibration; Python}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{Department of Chemical Engineering, Lund University}},
  school       = {{Lund University}},
  title        = {{Tools for digital twins in continuous downstream processing}},
  url          = {{https://lup.lub.lu.se/search/files/162287860/Simon_Tallvod_WEBB.pdf}},
  year         = {{2023}},
}