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Automation of Modeling and Calibration of Integrated Preparative Protein Chromatography Systems

Tallvod, Simon LU ; Andersson, Niklas LU orcid and Nilsson, Bernt LU (2022) In Processes 10(5).
Abstract

With the increasing global demand for precise and efficient pharmaceuticals and the biopharma industry moving towards Industry 4.0, the need for advanced process integration, automation, and modeling has increased as well. In this work, a method for automatic modeling and calibration of an integrated preparative chromatographic system for pharmaceutical development and production is presented. Based on a user-defined system description, a system model was automatically generated and then calibrated using a sequence of experiments. The system description and model was implemented in the Python-based preparative chromatography control software Orbit.

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
chromatography modeling, digital twin, integrated continuous processes, model calibration, preparative chromatography, process automation
in
Processes
volume
10
issue
5
article number
945
publisher
MDPI AG
external identifiers
  • scopus:85130254794
ISSN
2227-9717
DOI
10.3390/pr10050945
language
English
LU publication?
yes
id
f2307a8d-0245-4257-af87-e6a6e6260056
date added to LUP
2022-07-12 14:25:25
date last changed
2024-03-03 11:21:02
@article{f2307a8d-0245-4257-af87-e6a6e6260056,
  abstract     = {{<p>With the increasing global demand for precise and efficient pharmaceuticals and the biopharma industry moving towards Industry 4.0, the need for advanced process integration, automation, and modeling has increased as well. In this work, a method for automatic modeling and calibration of an integrated preparative chromatographic system for pharmaceutical development and production is presented. Based on a user-defined system description, a system model was automatically generated and then calibrated using a sequence of experiments. The system description and model was implemented in the Python-based preparative chromatography control software Orbit.</p>}},
  author       = {{Tallvod, Simon and Andersson, Niklas and Nilsson, Bernt}},
  issn         = {{2227-9717}},
  keywords     = {{chromatography modeling; digital twin; integrated continuous processes; model calibration; preparative chromatography; process automation}},
  language     = {{eng}},
  number       = {{5}},
  publisher    = {{MDPI AG}},
  series       = {{Processes}},
  title        = {{Automation of Modeling and Calibration of Integrated Preparative Protein Chromatography Systems}},
  url          = {{http://dx.doi.org/10.3390/pr10050945}},
  doi          = {{10.3390/pr10050945}},
  volume       = {{10}},
  year         = {{2022}},
}