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Fall risk-increasing drugs and falls: a cross-sectional study among elderly patients in primary care

Milos, Veronica LU ; Bondesson, Åsa ÅB LU ; Magnusson, Martina; Jakobsson, Ulf LU ; Westerlund, Tommy and Midlöv, Patrik LU (2014) In BMC Geriatrics 14.
Abstract
Background: Falls are the most common cause of injuries and hospital admissions in the elderly. The Swedish National Board of Health and Welfare has created a list of drugs considered to increase the fall risk (FRIDs) and drugs that might cause/worsen orthostatism (ODs). This cross-sectional study was aimed to assess FRIDs and their correlation with falls in a sample of 369 community-dwelling and nursing home patients aged >= 75 years and who were using a multi-dose drug dispensing system. Methods: Data were collected from the patients' electronic medication lists. Retrospective data on reported falls during the previous three months and severe falls during the previous 12 months were collected. Primary outcome measures were incidence... (More)
Background: Falls are the most common cause of injuries and hospital admissions in the elderly. The Swedish National Board of Health and Welfare has created a list of drugs considered to increase the fall risk (FRIDs) and drugs that might cause/worsen orthostatism (ODs). This cross-sectional study was aimed to assess FRIDs and their correlation with falls in a sample of 369 community-dwelling and nursing home patients aged >= 75 years and who were using a multi-dose drug dispensing system. Methods: Data were collected from the patients' electronic medication lists. Retrospective data on reported falls during the previous three months and severe falls during the previous 12 months were collected. Primary outcome measures were incidence of falls as well as numbers of FRIDs and ODs in fallers and non-fallers. Results: The studied sample had a high incidence of both reported falls (29%) and severe falls (17%). Patients were dispensed a mean of 2.2 (SD 1.5) FRIDs and 2.0 (SD 1.6) ODs. Fallers used on average more FRIDs. Severe falls were more common in nursing homes patients. More women than men experienced severe falls. There were positive associations between number of FRIDs and the total number of drugs (p < 0.01), severe falls (p < 0.01) and female sex (p = 0.03). There were also associations between number of ODs and both total number of drugs (p < 0.01) and being community dwelling (p = 0.02). No association was found between number of ODs and severe falls. Antidepressants and anxiolytics were the most frequently dispensed FRIDs. Conclusions: Fallers had a higher number of FRIDs. Numbers of FRIDs and ODs were correlated with the total number of drugs dispensed. Interventions to reduce falls in the elderly by focusing on reducing the total number of drugs and withdrawal of psychotropic medications might improve the quality and safety of drug treatment in primary care. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Elderly, Falls, Prevention, Drug therapy, Fall risk-increasing drugs
in
BMC Geriatrics
volume
14
publisher
BioMed Central
external identifiers
  • wos:000335555600001
  • scopus:84899092241
ISSN
1471-2318
DOI
10.1186/1471-2318-14-40
language
English
LU publication?
yes
id
771a66fd-da4d-42e0-a567-83a5dc6ccf9a (old id 4482249)
date added to LUP
2014-07-01 07:36:44
date last changed
2017-10-01 04:10:13
@article{771a66fd-da4d-42e0-a567-83a5dc6ccf9a,
  abstract     = {Background: Falls are the most common cause of injuries and hospital admissions in the elderly. The Swedish National Board of Health and Welfare has created a list of drugs considered to increase the fall risk (FRIDs) and drugs that might cause/worsen orthostatism (ODs). This cross-sectional study was aimed to assess FRIDs and their correlation with falls in a sample of 369 community-dwelling and nursing home patients aged &gt;= 75 years and who were using a multi-dose drug dispensing system. Methods: Data were collected from the patients' electronic medication lists. Retrospective data on reported falls during the previous three months and severe falls during the previous 12 months were collected. Primary outcome measures were incidence of falls as well as numbers of FRIDs and ODs in fallers and non-fallers. Results: The studied sample had a high incidence of both reported falls (29%) and severe falls (17%). Patients were dispensed a mean of 2.2 (SD 1.5) FRIDs and 2.0 (SD 1.6) ODs. Fallers used on average more FRIDs. Severe falls were more common in nursing homes patients. More women than men experienced severe falls. There were positive associations between number of FRIDs and the total number of drugs (p &lt; 0.01), severe falls (p &lt; 0.01) and female sex (p = 0.03). There were also associations between number of ODs and both total number of drugs (p &lt; 0.01) and being community dwelling (p = 0.02). No association was found between number of ODs and severe falls. Antidepressants and anxiolytics were the most frequently dispensed FRIDs. Conclusions: Fallers had a higher number of FRIDs. Numbers of FRIDs and ODs were correlated with the total number of drugs dispensed. Interventions to reduce falls in the elderly by focusing on reducing the total number of drugs and withdrawal of psychotropic medications might improve the quality and safety of drug treatment in primary care.},
  articleno    = {40},
  author       = {Milos, Veronica and Bondesson, Åsa ÅB and Magnusson, Martina and Jakobsson, Ulf and Westerlund, Tommy and Midlöv, Patrik},
  issn         = {1471-2318},
  keyword      = {Elderly,Falls,Prevention,Drug therapy,Fall risk-increasing drugs},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Geriatrics},
  title        = {Fall risk-increasing drugs and falls: a cross-sectional study among elderly patients in primary care},
  url          = {http://dx.doi.org/10.1186/1471-2318-14-40},
  volume       = {14},
  year         = {2014},
}