Temporal trends of sex disparity in incidence and survival of colorectal cancer : Variations by anatomical site and age at diagnosis
(2020) In Clinical Epidemiology 12. p.73-81- Abstract
Purpose: The incidence of colorectal cancer (CRC) varies by age, sex, and anatomical subsite. Few studies have examined the temporal trends of age-specific sex disparity in incidence and survival by age at diagnosis and anatomical site. Patients and Methods: The study was performed on all incident cases of CRC, using data derived from the nationwide Swedish Cancer Register between 1960 and 2014, including right-sided colon cancer (RCC), left-sided colon cancer (LCC), and rectal cancer. Male-to-female age-standardized incidence rate ratio (IRR) and male-to-female five-year survival rate ratio (SRR) were calculated as the main indicators. Furthermore, we performed joinpoint regression analyses to estimate average annual percentage change.... (More)
Purpose: The incidence of colorectal cancer (CRC) varies by age, sex, and anatomical subsite. Few studies have examined the temporal trends of age-specific sex disparity in incidence and survival by age at diagnosis and anatomical site. Patients and Methods: The study was performed on all incident cases of CRC, using data derived from the nationwide Swedish Cancer Register between 1960 and 2014, including right-sided colon cancer (RCC), left-sided colon cancer (LCC), and rectal cancer. Male-to-female age-standardized incidence rate ratio (IRR) and male-to-female five-year survival rate ratio (SRR) were calculated as the main indicators. Furthermore, we performed joinpoint regression analyses to estimate average annual percentage change. Results: The overall male-to-female IRR was 1.05 for RCC, 1.31 for LCC, and 1.66 for rectal cancer. Male-to-female IRR increased steadily for RCC by an average of 0.4% per year until the mid-1990s and then decreased gradually by an average of 1.0% per year. LCC patients showed an increase of 0.6% per year since the mid-1970s. For rectal cancer, a non-significant random fluctuation was noted during the study period. The temporal trends of male-to-female IRR varied by age at diagnosis. The male-to-female SRR was 0.87 for RCC, 0.88 for LCC, and 0.86 for rectal cancer, which remained relatively stable during the study period. Conclusion: Sex disparity of CRC is age-, period-, and anatomical subsite-dependent. Further studies are needed to investigate the underlying contributing factors.
(Less)
- author
- Sun, Ming LU ; Wang, Youxin ; Sundquist, Jan LU ; Sundquist, Kristina LU and Ji, Jianguang LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Colorectal cancer, Incidence, Sex disparity, Survival, Temporal trend
- in
- Clinical Epidemiology
- volume
- 12
- pages
- 73 - 81
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:32021473
- scopus:85078813175
- ISSN
- 1179-1349
- DOI
- 10.2147/CLEP.S240006
- language
- English
- LU publication?
- yes
- id
- 44a6749a-e58a-4eb2-9c2f-e3ee815b4a14
- date added to LUP
- 2020-02-14 15:39:15
- date last changed
- 2024-03-04 13:50:55
@article{44a6749a-e58a-4eb2-9c2f-e3ee815b4a14, abstract = {{<p>Purpose: The incidence of colorectal cancer (CRC) varies by age, sex, and anatomical subsite. Few studies have examined the temporal trends of age-specific sex disparity in incidence and survival by age at diagnosis and anatomical site. Patients and Methods: The study was performed on all incident cases of CRC, using data derived from the nationwide Swedish Cancer Register between 1960 and 2014, including right-sided colon cancer (RCC), left-sided colon cancer (LCC), and rectal cancer. Male-to-female age-standardized incidence rate ratio (IRR) and male-to-female five-year survival rate ratio (SRR) were calculated as the main indicators. Furthermore, we performed joinpoint regression analyses to estimate average annual percentage change. Results: The overall male-to-female IRR was 1.05 for RCC, 1.31 for LCC, and 1.66 for rectal cancer. Male-to-female IRR increased steadily for RCC by an average of 0.4% per year until the mid-1990s and then decreased gradually by an average of 1.0% per year. LCC patients showed an increase of 0.6% per year since the mid-1970s. For rectal cancer, a non-significant random fluctuation was noted during the study period. The temporal trends of male-to-female IRR varied by age at diagnosis. The male-to-female SRR was 0.87 for RCC, 0.88 for LCC, and 0.86 for rectal cancer, which remained relatively stable during the study period. Conclusion: Sex disparity of CRC is age-, period-, and anatomical subsite-dependent. Further studies are needed to investigate the underlying contributing factors.</p>}}, author = {{Sun, Ming and Wang, Youxin and Sundquist, Jan and Sundquist, Kristina and Ji, Jianguang}}, issn = {{1179-1349}}, keywords = {{Colorectal cancer; Incidence; Sex disparity; Survival; Temporal trend}}, language = {{eng}}, pages = {{73--81}}, publisher = {{Dove Medical Press Ltd.}}, series = {{Clinical Epidemiology}}, title = {{Temporal trends of sex disparity in incidence and survival of colorectal cancer : Variations by anatomical site and age at diagnosis}}, url = {{http://dx.doi.org/10.2147/CLEP.S240006}}, doi = {{10.2147/CLEP.S240006}}, volume = {{12}}, year = {{2020}}, }