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Charting the human respiratory tract with airborne nanoparticles : Evaluation of the Airspace Dimension Assessment technique

Jakobsson, Jonas LU ; Wollmer, Per LU and Löndahl, Jakob LU (2018) In Journal of Applied Physiology 125(6). p.1832-1840
Abstract


Airspace Dimension Assessment (AiDA) is a technique to assess lung morphology by measuring lung deposition of inhaled nanoparticles. Nanoparticles deposit in the lungs predominately by diffusion, and average diffusion distances, corresponding to effective airspace radii (rAiDA), can be inferred from measurements of particle recovery after varied breath holds. Also, particle recovery after a 0-s breath hold (R0) may hold information about the small conducting airways. This study investigates rAiDA at different volumetric sample depths in the lungs of healthy subjects. Measurements were performed with 50-nm polystyrene nanospheres on 19 healthy subjects aged 17– 67 yr.... (More)


Airspace Dimension Assessment (AiDA) is a technique to assess lung morphology by measuring lung deposition of inhaled nanoparticles. Nanoparticles deposit in the lungs predominately by diffusion, and average diffusion distances, corresponding to effective airspace radii (rAiDA), can be inferred from measurements of particle recovery after varied breath holds. Also, particle recovery after a 0-s breath hold (R0) may hold information about the small conducting airways. This study investigates rAiDA at different volumetric sample depths in the lungs of healthy subjects. Measurements were performed with 50-nm polystyrene nanospheres on 19 healthy subjects aged 17– 67 yr. Volumetric sample depths ranged from 200 to 5,000 ml and breath-hold times from 5 to 20 s. At the examined volumetric sample depths, rAiDA values ranged from ~200 – 600 m, which correspond to dimensions of the bronchiolar and the gas-exchanging regions of the lungs. R
0
decreased with volumetric sample depth and showed more intersubject variation than rAiDA. Correlations were found between the AiDA parameters, anthropometry, and lung function tests, but not between rAiDA and R0. For repeated measurements on 3 subjects over an 18-mo period, rAiDA varied on average within 7 m ( 2.4%). The results indicate that AiDA has potential as an efficient new in vivo technique to assess individual lung properties. The information obtained by such measurements may be of value for lung diagnostics, especially for the distal lungs, which are challenging to examine directly by other means. NEW & NOTEWORTHY This is the first study to measure effective airspace radii (rAiDA) at volumetric sample depths 200 –5,000 ml in healthy subjects by Airspace Dimension Assessment (AiDA). Observed rAiDA were 200 – 600 m, which corresponds to airspaces for the bronchiolar and the gas-exchanging regions around airway generation 14 –17. rAiDA correlated with lung function tests and anthropometry. Measurements of rAiDA on 3 subjects over 11–18 mo were within 7 m.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aerosol, Airspace Dimension Assessment (AiDA), Lung deposition, Lung morphometry, Nanoparticles
in
Journal of Applied Physiology
volume
125
issue
6
pages
9 pages
publisher
American Physiological Society
external identifiers
  • scopus:85061318480
ISSN
8750-7587
DOI
10.1152/japplphysiol.00410.2018
language
English
LU publication?
yes
id
44c53e0f-ba84-48b0-aebc-2e1341485cdb
date added to LUP
2019-02-19 15:05:23
date last changed
2019-05-17 10:55:54
@article{44c53e0f-ba84-48b0-aebc-2e1341485cdb,
  abstract     = {<p><br>
                                                         Airspace Dimension Assessment (AiDA) is a technique to assess lung morphology by measuring lung deposition of inhaled nanoparticles. Nanoparticles deposit in the lungs predominately by diffusion, and average diffusion distances, corresponding to effective airspace radii (rAiDA), can be inferred from measurements of particle recovery after varied breath holds. Also, particle recovery after a 0-s breath hold (R0) may hold information about the small conducting airways. This study investigates rAiDA at different volumetric sample depths in the lungs of healthy subjects. Measurements were performed with 50-nm polystyrene nanospheres on 19 healthy subjects aged 17– 67 yr. Volumetric sample depths ranged from 200 to 5,000 ml and breath-hold times from 5 to 20 s. At the examined volumetric sample depths, rAiDA values ranged from ~200 – 600 m, which correspond to dimensions of the bronchiolar and the gas-exchanging regions of the lungs. R                             <br>
                            <sub>0</sub><br>
                                                          decreased with volumetric sample depth and showed more intersubject variation than rAiDA. Correlations were found between the AiDA parameters, anthropometry, and lung function tests, but not between rAiDA and R0. For repeated measurements on 3 subjects over an 18-mo period, rAiDA varied on average within 7 m ( 2.4%). The results indicate that AiDA has potential as an efficient new in vivo technique to assess individual lung properties. The information obtained by such measurements may be of value for lung diagnostics, especially for the distal lungs, which are challenging to examine directly by other means. NEW &amp; NOTEWORTHY This is the first study to measure effective airspace radii (rAiDA) at volumetric sample depths 200 –5,000 ml in healthy subjects by Airspace Dimension Assessment (AiDA). Observed rAiDA were 200 – 600 m, which corresponds to airspaces for the bronchiolar and the gas-exchanging regions around airway generation 14 –17. rAiDA correlated with lung function tests and anthropometry. Measurements of rAiDA on 3 subjects over 11–18 mo were within 7 m.                         <br>
                        </p>},
  author       = {Jakobsson, Jonas and Wollmer, Per and Löndahl, Jakob},
  issn         = {8750-7587},
  keyword      = {Aerosol,Airspace Dimension Assessment (AiDA),Lung deposition,Lung morphometry,Nanoparticles},
  language     = {eng},
  number       = {6},
  pages        = {1832--1840},
  publisher    = {American Physiological Society},
  series       = {Journal of Applied Physiology},
  title        = {Charting the human respiratory tract with airborne nanoparticles : Evaluation of the Airspace Dimension Assessment technique},
  url          = {http://dx.doi.org/10.1152/japplphysiol.00410.2018},
  volume       = {125},
  year         = {2018},
}