Mortality and Inherited Thrombophilia: results from the European Prospective Cohort on Thrombophilia (EPCOT).
(2012) In Journal of Thrombosis and Haemostasis 10(2). p.217-222- Abstract
- Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of this study the vital status was assessed in 1,240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin-, 341 with protein C-, 276 with protein S-deficiency, 330 with factor V Leiden and 97 with... (More)
- Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of this study the vital status was assessed in 1,240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin-, 341 with protein C-, 276 with protein S-deficiency, 330 with factor V Leiden and 97 with combined defects, 62% with a VT history) and 875 controls (mean age 42.5 years, 48% women, 7% with a VT history). Results: Seventy-two individuals with thrombophilia and 45 controls died during follow-up. The risk of death, adjusted for sex, thrombosis-history and centre, was not associated with thrombophilia (hazard ratio (HR) thrombophilia individuals versus controls: 1.09, 95% confidence interval (CI) 0.66-1.78). When individuals with thrombophilia were evaluated separately, a history of thrombosis was not associated with mortality: the risk of death after adjustment for sex, anticoagulation and center was HR 0.79 (95% CI 0.41-1.54). Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2274784
- author
- Pabinger, I ; Vossen, C Y ; Lang, J ; Conard, J ; García-Dabrio, M C ; Miesbach, W ; Legnani, C ; Svensson, Peter LU ; Kaider, A and Rosendaal, F R
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- deep vein thrombosis mortality, pulmonary embolism, survival, thrombophilia, venous thromboembolism
- in
- Journal of Thrombosis and Haemostasis
- volume
- 10
- issue
- 2
- pages
- 217 - 222
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000299779500006
- pmid:22128841
- scopus:84856554503
- pmid:22128841
- ISSN
- 1538-7933
- DOI
- 10.1111/j.1538-7836.2011.04573.x
- language
- English
- LU publication?
- yes
- id
- 44fb4e11-0d72-4222-a5cb-9c1a2b5906e0 (old id 2274784)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22128841?dopt=Abstract
- date added to LUP
- 2016-04-01 11:06:46
- date last changed
- 2022-01-26 05:27:44
@article{44fb4e11-0d72-4222-a5cb-9c1a2b5906e0,
abstract = {{Background: Data on the survival of individuals with hereditary thrombophilia are rare and only come from retrospective studies. Objective: We aimed to assess mortality in individuals with known thrombophilia with and without a history of thrombosis in comparison to a control group. Patients/Methods: The European Prospective Cohort on Thrombophilia (EPCOT) study is a prospective multi-centre observational study performed to assess the risk of thrombosis in persons with inherited thrombophilia. In an extension of this study the vital status was assessed in 1,240 individuals with thrombophilia (mean age 40.9 years, 59% women, 196 with antithrombin-, 341 with protein C-, 276 with protein S-deficiency, 330 with factor V Leiden and 97 with combined defects, 62% with a VT history) and 875 controls (mean age 42.5 years, 48% women, 7% with a VT history). Results: Seventy-two individuals with thrombophilia and 45 controls died during follow-up. The risk of death, adjusted for sex, thrombosis-history and centre, was not associated with thrombophilia (hazard ratio (HR) thrombophilia individuals versus controls: 1.09, 95% confidence interval (CI) 0.66-1.78). When individuals with thrombophilia were evaluated separately, a history of thrombosis was not associated with mortality: the risk of death after adjustment for sex, anticoagulation and center was HR 0.79 (95% CI 0.41-1.54). Conclusions: No increased risk of death in individuals with thrombophilia, not even in those with a history of thrombosis, was observed.}},
author = {{Pabinger, I and Vossen, C Y and Lang, J and Conard, J and García-Dabrio, M C and Miesbach, W and Legnani, C and Svensson, Peter and Kaider, A and Rosendaal, F R}},
issn = {{1538-7933}},
keywords = {{deep vein thrombosis mortality; pulmonary embolism; survival; thrombophilia; venous thromboembolism}},
language = {{eng}},
number = {{2}},
pages = {{217--222}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Thrombosis and Haemostasis}},
title = {{Mortality and Inherited Thrombophilia: results from the European Prospective Cohort on Thrombophilia (EPCOT).}},
url = {{http://dx.doi.org/10.1111/j.1538-7836.2011.04573.x}},
doi = {{10.1111/j.1538-7836.2011.04573.x}},
volume = {{10}},
year = {{2012}},
}