Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
(2017) In Journal of Diabetes Research p.1-12- Abstract
- Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75 g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3 g/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27 ± 6.3 years, BMI 23.6 ± 3.2 kg/m2). LAR was negatively associated with HOMA-S (; ), Matsuda-ISICOMP (; ), and the calculated sensitivity index (CSi) derived from IVGTT (; ).... (More)
- Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75 g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3 g/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27 ± 6.3 years, BMI 23.6 ± 3.2 kg/m2). LAR was negatively associated with HOMA-S (; ), Matsuda-ISICOMP (; ), and the calculated sensitivity index (CSi) derived from IVGTT (; ). In comparison to LAR, leptin/HMWA ratio did not increase neither the linear fit () nor the magnitude of association with insulin sensitivity indexes (slope of multiple linear regression). The discriminatory capacity of both ratios to classify insulin-resistant versus insulin-sensitive subjects was similar for HOMA-S (), Matsuda-ISICOMP (), or CSi (). In conclusion, LAR showed consistent negative associations with different systemic insulin sensitivity indexes. The use of HMWA to generate leptin/HMWA ratio did not show any advantage over LAR as a biomarker of systemic insulin sensitivity in normoglycemic women (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/45157113-948b-4b56-b7b4-558d410ce6c2
- author
- Bravo, Carolina
; Cataldo, Luis Rodrigo
LU
; Galgani, José ; Parada, Javier and Santos, José Luis
- organization
- publishing date
- 2017-05-25
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- leptin, adioponectin, biomarker, Insulin sensitivity
- in
- Journal of Diabetes Research
- pages
- 11 pages
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:28626772
- scopus:85021766520
- ISSN
- 2314-6753
- DOI
- 10.1155/2017/9031079
- language
- English
- LU publication?
- yes
- id
- 45157113-948b-4b56-b7b4-558d410ce6c2
- date added to LUP
- 2017-06-20 18:04:36
- date last changed
- 2022-07-18 20:17:45
@article{45157113-948b-4b56-b7b4-558d410ce6c2, abstract = {{Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75 g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3 g/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27 ± 6.3 years, BMI 23.6 ± 3.2 kg/m2). LAR was negatively associated with HOMA-S (; ), Matsuda-ISICOMP (; ), and the calculated sensitivity index (CSi) derived from IVGTT (; ). In comparison to LAR, leptin/HMWA ratio did not increase neither the linear fit () nor the magnitude of association with insulin sensitivity indexes (slope of multiple linear regression). The discriminatory capacity of both ratios to classify insulin-resistant versus insulin-sensitive subjects was similar for HOMA-S (), Matsuda-ISICOMP (), or CSi (). In conclusion, LAR showed consistent negative associations with different systemic insulin sensitivity indexes. The use of HMWA to generate leptin/HMWA ratio did not show any advantage over LAR as a biomarker of systemic insulin sensitivity in normoglycemic women}}, author = {{Bravo, Carolina and Cataldo, Luis Rodrigo and Galgani, José and Parada, Javier and Santos, José Luis}}, issn = {{2314-6753}}, keywords = {{leptin; adioponectin; biomarker; Insulin sensitivity}}, language = {{eng}}, month = {{05}}, pages = {{1--12}}, publisher = {{Hindawi Limited}}, series = {{Journal of Diabetes Research}}, title = {{Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women}}, url = {{http://dx.doi.org/10.1155/2017/9031079}}, doi = {{10.1155/2017/9031079}}, year = {{2017}}, }