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Severe Traumatic Brain Injury Management and Clinical Outcome Using the Lund Concept.

Koskinen, L-O D; Olivecrona, M and Grände, Per-Olof LU (2014) In Neuroscience 283(Jun 25). p.245-255
Abstract
This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results from clinical studies in which this therapy or a modified version of the therapy has been used. Unlike other guidelines, which are based on meta-analytical approaches, important components of the Lund concept are based on physiological mechanisms for regulation of brain volume and brain perfusion and to reduce transcapillary plasma leakage and the need for plasma volume expanders. There have been 8 non-randomised and 2 randomised outcome studies with the Lund concept or modified versions of the concept. The non-randomised studies indicated that the Lund concept is beneficial for outcome.... (More)
This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results from clinical studies in which this therapy or a modified version of the therapy has been used. Unlike other guidelines, which are based on meta-analytical approaches, important components of the Lund concept are based on physiological mechanisms for regulation of brain volume and brain perfusion and to reduce transcapillary plasma leakage and the need for plasma volume expanders. There have been 8 non-randomised and 2 randomised outcome studies with the Lund concept or modified versions of the concept. The non-randomised studies indicated that the Lund concept is beneficial for outcome. The 2 randomised studies were small but showed better outcome in the groups of patients treated according to the modified principles of the Lund concept than in the groups given a more conventional treatment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscience
volume
283
issue
Jun 25
pages
245 - 255
publisher
Elsevier
external identifiers
  • pmid:24973658
  • wos:000345513100018
  • scopus:84911911686
ISSN
1873-7544
DOI
10.1016/j.neuroscience.2014.06.039
language
English
LU publication?
yes
id
1fa33572-ce08-43e1-a4ef-37a00ba956d2 (old id 4523656)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24973658?dopt=Abstract
date added to LUP
2014-07-08 16:30:00
date last changed
2017-08-27 03:32:42
@article{1fa33572-ce08-43e1-a4ef-37a00ba956d2,
  abstract     = {This review covers the main principles of the Lund concept for treatment of severe traumatic brain injury. This is followed by a description of results from clinical studies in which this therapy or a modified version of the therapy has been used. Unlike other guidelines, which are based on meta-analytical approaches, important components of the Lund concept are based on physiological mechanisms for regulation of brain volume and brain perfusion and to reduce transcapillary plasma leakage and the need for plasma volume expanders. There have been 8 non-randomised and 2 randomised outcome studies with the Lund concept or modified versions of the concept. The non-randomised studies indicated that the Lund concept is beneficial for outcome. The 2 randomised studies were small but showed better outcome in the groups of patients treated according to the modified principles of the Lund concept than in the groups given a more conventional treatment.},
  author       = {Koskinen, L-O D and Olivecrona, M and Grände, Per-Olof},
  issn         = {1873-7544},
  language     = {eng},
  number       = {Jun 25},
  pages        = {245--255},
  publisher    = {Elsevier},
  series       = {Neuroscience},
  title        = {Severe Traumatic Brain Injury Management and Clinical Outcome Using the Lund Concept.},
  url          = {http://dx.doi.org/10.1016/j.neuroscience.2014.06.039},
  volume       = {283},
  year         = {2014},
}