Number of Nexin Links Detectable at Standard Electron Microscopy of Normal Human Nasal Cilia and at Nexin Link Deficiency.
(2014) In Ultrastructural Pathology 38(6). p.377-381- Abstract
- Abstract Background: Eleven years ago we had described three patients with missing nexin links as a possible cause of primary ciliary dyskinesia (PCD). The assumption was substantiated last year by finding a mutation in these patients. Materials and Methods: We counted the nexin links, inner (IDA) and outer (ODA) dynein arms and microtubuli in each of, if possible, 50 cilia in 41 patients with normal cilia, 4 patients with deficiency of nexin links only and 4 with deficiency of nexin links and IDA. Results: In the control group the median number of nexin links was 4.5 per cilium, range 3.4-5.3. In the second group the mean numbers of nexin links per cilium were 1.1-1.4, in the third group 0.8-1.2, per patient. The median number of IDA was... (More)
- Abstract Background: Eleven years ago we had described three patients with missing nexin links as a possible cause of primary ciliary dyskinesia (PCD). The assumption was substantiated last year by finding a mutation in these patients. Materials and Methods: We counted the nexin links, inner (IDA) and outer (ODA) dynein arms and microtubuli in each of, if possible, 50 cilia in 41 patients with normal cilia, 4 patients with deficiency of nexin links only and 4 with deficiency of nexin links and IDA. Results: In the control group the median number of nexin links was 4.5 per cilium, range 3.4-5.3. In the second group the mean numbers of nexin links per cilium were 1.1-1.4, in the third group 0.8-1.2, per patient. The median number of IDA was in the control group 4.2, range 3.3-5.2. In groups 2 and 3 the numbers were 3.0-3.5 and 0.2-1.0, respectively. Numbers of ODA were normal in all groups. Conclusions: It is possible to reliable count the number of nexin links in nasal human cilia and to distinguish cases with missing nexin links from normal controls. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4526671
- author
- Cramnert, Catharina and Stenram, Unne LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Ultrastructural Pathology
- volume
- 38
- issue
- 6
- pages
- 377 - 381
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:24971518
- wos:000345348200002
- scopus:84911460763
- pmid:24971518
- ISSN
- 1521-0758
- DOI
- 10.3109/01913123.2014.930081
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- 25208a57-8d2e-44fb-83cc-cbc016da6310 (old id 4526671)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24971518?dopt=Abstract
- date added to LUP
- 2016-04-01 09:55:20
- date last changed
- 2025-04-04 14:12:42
@article{25208a57-8d2e-44fb-83cc-cbc016da6310,
abstract = {{Abstract Background: Eleven years ago we had described three patients with missing nexin links as a possible cause of primary ciliary dyskinesia (PCD). The assumption was substantiated last year by finding a mutation in these patients. Materials and Methods: We counted the nexin links, inner (IDA) and outer (ODA) dynein arms and microtubuli in each of, if possible, 50 cilia in 41 patients with normal cilia, 4 patients with deficiency of nexin links only and 4 with deficiency of nexin links and IDA. Results: In the control group the median number of nexin links was 4.5 per cilium, range 3.4-5.3. In the second group the mean numbers of nexin links per cilium were 1.1-1.4, in the third group 0.8-1.2, per patient. The median number of IDA was in the control group 4.2, range 3.3-5.2. In groups 2 and 3 the numbers were 3.0-3.5 and 0.2-1.0, respectively. Numbers of ODA were normal in all groups. Conclusions: It is possible to reliable count the number of nexin links in nasal human cilia and to distinguish cases with missing nexin links from normal controls.}},
author = {{Cramnert, Catharina and Stenram, Unne}},
issn = {{1521-0758}},
language = {{eng}},
number = {{6}},
pages = {{377--381}},
publisher = {{Taylor & Francis}},
series = {{Ultrastructural Pathology}},
title = {{Number of Nexin Links Detectable at Standard Electron Microscopy of Normal Human Nasal Cilia and at Nexin Link Deficiency.}},
url = {{http://dx.doi.org/10.3109/01913123.2014.930081}},
doi = {{10.3109/01913123.2014.930081}},
volume = {{38}},
year = {{2014}},
}