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Plants salvage deoxyribonucleosides in mitochondria.

Clausen, Anders Ranegaard LU ; Mutahir, Zeeshan LU ; Munch-Petersen, Birgitte LU and Piskur, Jure LU (2014) In Nucleosides, Nucleotides & Nucleic Acids 33(4-6). p.291-295
Abstract
Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the... (More)
Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the mitochondrion suggests that plants have a different organization of the deoxyribonucleoside salvage compared to mammals. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nucleosides, Nucleotides & Nucleic Acids
volume
33
issue
4-6
pages
291 - 295
publisher
Taylor & Francis
external identifiers
  • pmid:24940682
  • wos:000337939200018
  • scopus:84903166296
ISSN
1525-7770
DOI
10.1080/15257770.2013.853782
language
English
LU publication?
yes
id
b3c8f8a5-2e7e-43d8-a443-0fb986feaf0f (old id 4528223)
date added to LUP
2014-08-12 09:01:40
date last changed
2017-01-01 03:44:01
@article{b3c8f8a5-2e7e-43d8-a443-0fb986feaf0f,
  abstract     = {Deoxyribonucleoside kinases phosphorylate deoxyribonucleosides into the corresponding 5'-monophosphate deoxyribonucleosides to supply the cell with nucleic acid precursors. In mitochondrial fractions of the model plant Arabidopsis thaliana, we detected deoxyadenosine and thymidine kinase activities, while the cytosol fraction contained six-fold lower activity and chloroplasts contained no measurable activities. In addition, a mitochondrial fraction isolated from the potato Solanum tuberosum contained thymidine kinase and deoxyadenosine kinase activities. We conclude that an active salvage of deoxyribonucleosides in plants takes place in their mitochondria. In general, the observed localization of the plant dNK activities in the mitochondrion suggests that plants have a different organization of the deoxyribonucleoside salvage compared to mammals.},
  author       = {Clausen, Anders Ranegaard and Mutahir, Zeeshan and Munch-Petersen, Birgitte and Piskur, Jure},
  issn         = {1525-7770},
  language     = {eng},
  number       = {4-6},
  pages        = {291--295},
  publisher    = {Taylor & Francis},
  series       = {Nucleosides, Nucleotides & Nucleic Acids},
  title        = {Plants salvage deoxyribonucleosides in mitochondria.},
  url          = {http://dx.doi.org/10.1080/15257770.2013.853782},
  volume       = {33},
  year         = {2014},
}