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Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.

Omar, Bilal LU ; Liehua, Liu; Yamada, Yuchiro; Seino, Yutaka; Marchetti, Piero and Ahrén, Bo LU (2014) In Diabetologia 57(9). p.1876-1883
Abstract
Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4), which cleaves and inactivates glucagon-like peptide 1 (GLP-1), is a glucose-lowering strategy in type 2 diabetes. Since DPP-4 is a ubiquitously distributed enzyme, we examined whether it is expressed in islets and whether an islet effect to inhibit DPP-4 may result in stimulated insulin secretion.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
57
issue
9
pages
1876 - 1883
publisher
Springer Verlag
external identifiers
  • pmid:24939431
  • wos:000340050800018
  • scopus:84905576401
ISSN
1432-0428
DOI
10.1007/s00125-014-3299-4
language
English
LU publication?
yes
id
412919aa-64e6-4cd5-95fc-55c532a33c39 (old id 4528268)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24939431?dopt=Abstract
date added to LUP
2014-07-06 13:02:05
date last changed
2017-02-26 03:10:28
@article{412919aa-64e6-4cd5-95fc-55c532a33c39,
  abstract     = {Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4), which cleaves and inactivates glucagon-like peptide 1 (GLP-1), is a glucose-lowering strategy in type 2 diabetes. Since DPP-4 is a ubiquitously distributed enzyme, we examined whether it is expressed in islets and whether an islet effect to inhibit DPP-4 may result in stimulated insulin secretion.},
  author       = {Omar, Bilal and Liehua, Liu and Yamada, Yuchiro and Seino, Yutaka and Marchetti, Piero and Ahrén, Bo},
  issn         = {1432-0428},
  language     = {eng},
  number       = {9},
  pages        = {1876--1883},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Dipeptidyl peptidase 4 (DPP-4) is expressed in mouse and human islets and its activity is decreased in human islets from individuals with type 2 diabetes.},
  url          = {http://dx.doi.org/10.1007/s00125-014-3299-4},
  volume       = {57},
  year         = {2014},
}