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Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

Obón-Santacana, M; Kaaks, R; Slimani, N; Lujan-Barroso, L; Freisling, H; Ferrari, P; Dossus, L; Chabbert-Buffet, N; Baglietto, L and Fortner, R T, et al. (2014) In British Journal of Cancer 111(5). p.987-997
Abstract
Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC... (More)
Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com. (Less)
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British Journal of Cancer
volume
111
issue
5
pages
987 - 997
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Nature Publishing Group
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  • pmid:24937665
  • wos:000341527100023
  • scopus:84906939536
ISSN
1532-1827
DOI
10.1038/bjc.2014.328
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English
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93eb55a0-3833-49da-8c8e-a896ba73b942 (old id 4528309)
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http://www.ncbi.nlm.nih.gov/pubmed/24937665?dopt=Abstract
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2014-07-06 12:28:09
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2017-11-12 03:01:17
@article{93eb55a0-3833-49da-8c8e-a896ba73b942,
  abstract     = {Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com.},
  author       = {Obón-Santacana, M and Kaaks, R and Slimani, N and Lujan-Barroso, L and Freisling, H and Ferrari, P and Dossus, L and Chabbert-Buffet, N and Baglietto, L and Fortner, R T and Boeing, H and Tjønneland, A and Olsen, A and Overvad, K and Menéndez, V and Molina-Montes, E and Larrañaga, N and Chirlaque, M-D and Ardanaz, E and Khaw, K-T and Wareham, N and Travis, R C and Lu, Y and Merritt, M A and Trichopoulou, A and Benetou, V and Trichopoulos, D and Saieva, C and Sieri, S and Tumino, R and Sacerdote, C and Galasso, R and Bueno-de-Mesquita, H B and Wirfält, Elisabet and Ericson, Ulrika and Idahl, A and Ohlson, N and Skeie, G and Gram, I T and Weiderpass, E and Onland-Moret, N C and Riboli, E and Duell, E J},
  issn         = {1532-1827},
  language     = {eng},
  number       = {5},
  pages        = {987--997},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.},
  url          = {http://dx.doi.org/10.1038/bjc.2014.328},
  volume       = {111},
  year         = {2014},
}