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Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts.

Andersson, Gustav LU ; Wennersten, Christoffer ; Gaber, Alexander LU ; Boman, Karolina LU ; Nodin, Björn LU ; Uhlén, Mathias ; Segersten, Ulrika ; Malmström, Per LU and Jirström, Karin LU (2014) In BMC Urology 14(1).
Abstract
Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcinoma of the bladder treated with non-maintenance Bacillus Calmette-Guérin (n = 92), and the associations with adverse clinicopathological factors have been validated in another, unselected, cohort (n = 104). In the present study, we examined the prognostic significance of ezrin expression in urothelial bladder cancer in a total number of 442 tumours from two independent patient cohorts.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Urology
volume
14
issue
1
article number
36
publisher
BioMed Central (BMC)
external identifiers
  • pmid:24885195
  • wos:000337474600001
  • scopus:84902284556
  • pmid:24885195
ISSN
1471-2490
DOI
10.1186/1471-2490-14-36
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Oncology, MV (013035000), Pathology, (Lund) (013030000)
id
08431305-4761-464c-89bc-287cd1209fb2 (old id 4529533)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24885195?dopt=Abstract
date added to LUP
2016-04-01 14:03:03
date last changed
2020-09-02 02:11:34
@article{08431305-4761-464c-89bc-287cd1209fb2,
  abstract     = {Reduced membranous expression of the cytoskeleton-associated protein ezrin has previously been demonstrated to correlate with tumour progression and poor prognosis in patients with T1G3 urothelial cell carcinoma of the bladder treated with non-maintenance Bacillus Calmette-Guérin (n = 92), and the associations with adverse clinicopathological factors have been validated in another, unselected, cohort (n = 104). In the present study, we examined the prognostic significance of ezrin expression in urothelial bladder cancer in a total number of 442 tumours from two independent patient cohorts.},
  author       = {Andersson, Gustav and Wennersten, Christoffer and Gaber, Alexander and Boman, Karolina and Nodin, Björn and Uhlén, Mathias and Segersten, Ulrika and Malmström, Per and Jirström, Karin},
  issn         = {1471-2490},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central (BMC)},
  series       = {BMC Urology},
  title        = {Reduced expression of ezrin in urothelial bladder cancer signifies more advanced tumours and an impaired survival: validatory study of two independent patient cohorts.},
  url          = {https://lup.lub.lu.se/search/ws/files/3743906/5147882},
  doi          = {10.1186/1471-2490-14-36},
  volume       = {14},
  year         = {2014},
}