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Intervention on toll-like receptors in pancreatic cancer

Vaz, Juan LU and Andersson, Roland LU (2014) In World Journal of Gastroenterology 20(19). p.5808-5817
Abstract
Pancreatic ductal adenocarcinoma (PDA) is a devastating disease with pronounced morbidity and a high mortality rate. Currently available treatments lack convincing cost-efficiency determinations and are in most cases not associated with relevant success rate. Experimental stimulation of the immune system in murine PDA models has revealed some promising results. Toll-like receptors (TLRs) are pillars of the immune system that have been linked to several forms of malignancy, including lung, breast and colon cancer. In humans, TLRs are expressed in the pancreatic cancer tissue and in several cancer cell lines, whereas they are not expressed in the normal pancreas. In the present review, we explore the current knowledge concerning the role of... (More)
Pancreatic ductal adenocarcinoma (PDA) is a devastating disease with pronounced morbidity and a high mortality rate. Currently available treatments lack convincing cost-efficiency determinations and are in most cases not associated with relevant success rate. Experimental stimulation of the immune system in murine PDA models has revealed some promising results. Toll-like receptors (TLRs) are pillars of the immune system that have been linked to several forms of malignancy, including lung, breast and colon cancer. In humans, TLRs are expressed in the pancreatic cancer tissue and in several cancer cell lines, whereas they are not expressed in the normal pancreas. In the present review, we explore the current knowledge concerning the role of different TLRs associated to PDA. Even if almost all known TLRs are expressed in the pancreatic cancer microenvironment, there are only five TLRs suggested as possible therapeutic targets. Most data points at TLR2 and TLR9 as effective tumor markers and agonists could potentially be used as e.g. future adjuvant therapies. The elucidation of the role of TLR3 in PDA is only in its initial phase. The inhibition/blockage of TLR4-related pathways has shown some promising effects, but there are still many steps left before TLR4 inhibitors can be considered as possible therapeutic agents. Finally, TLR7 antagonists seem to be potential candidates for therapy. Independent of their potential in immunotherapies, all existing data indicate that TLRs are strongly involved in the pathophysiology and development of PDA. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adjuvant therapy, Intervention, Pancreatic cancer, Pathophysiological mechanism, Toll-like receptor
in
World Journal of Gastroenterology
volume
20
issue
19
pages
5808 - 5817
publisher
WJG Press
external identifiers
  • scopus:84901236766
  • pmid:24914341
  • wos:000336048200026
ISSN
1007-9327
DOI
10.3748/wjg.v20.i19.5808
language
English
LU publication?
yes
id
3a616a36-4cfb-4389-8d96-6dd74024e123 (old id 4530198)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24914341
http://www.wjgnet.com/1007-9327/pdf/v20/i19/5808.pdf
date added to LUP
2015-04-13 10:37:45
date last changed
2017-11-12 03:00:49
@article{3a616a36-4cfb-4389-8d96-6dd74024e123,
  abstract     = {Pancreatic ductal adenocarcinoma (PDA) is a devastating disease with pronounced morbidity and a high mortality rate. Currently available treatments lack convincing cost-efficiency determinations and are in most cases not associated with relevant success rate. Experimental stimulation of the immune system in murine PDA models has revealed some promising results. Toll-like receptors (TLRs) are pillars of the immune system that have been linked to several forms of malignancy, including lung, breast and colon cancer. In humans, TLRs are expressed in the pancreatic cancer tissue and in several cancer cell lines, whereas they are not expressed in the normal pancreas. In the present review, we explore the current knowledge concerning the role of different TLRs associated to PDA. Even if almost all known TLRs are expressed in the pancreatic cancer microenvironment, there are only five TLRs suggested as possible therapeutic targets. Most data points at TLR2 and TLR9 as effective tumor markers and agonists could potentially be used as e.g. future adjuvant therapies. The elucidation of the role of TLR3 in PDA is only in its initial phase. The inhibition/blockage of TLR4-related pathways has shown some promising effects, but there are still many steps left before TLR4 inhibitors can be considered as possible therapeutic agents. Finally, TLR7 antagonists seem to be potential candidates for therapy. Independent of their potential in immunotherapies, all existing data indicate that TLRs are strongly involved in the pathophysiology and development of PDA.},
  author       = {Vaz, Juan and Andersson, Roland},
  issn         = {1007-9327},
  keyword      = {Adjuvant therapy,Intervention,Pancreatic cancer,Pathophysiological mechanism,Toll-like receptor},
  language     = {eng},
  number       = {19},
  pages        = {5808--5817},
  publisher    = {WJG Press},
  series       = {World Journal of Gastroenterology},
  title        = {Intervention on toll-like receptors in pancreatic cancer},
  url          = {http://dx.doi.org/10.3748/wjg.v20.i19.5808},
  volume       = {20},
  year         = {2014},
}