Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies.
Brunnström, Hans LU
; Hansson, Oskar
LU
; Zetterberg, Henrik
; Londos, Elisabet
LU
and Englund, Elisabet
LU
(2013)
In International Journal of Geriatric Psychiatry
28(7).
p.738-744
- Abstract
- OBJECTIVE:
The presence of concomitant Alzheimer pathology has been linked to earlier death in cases with dementia with Lewy bodies (DLB). Recently, elevated cerebrospinal fluid (CSF) tau protein levels have been reported to be associated with shorter survival in clinically diagnosed DLB. Correlations between CSF biomarkers and neuropathological findings in DLB are missing. The aim of this study was to investigate correlations between CSF biomarker levels and histopathological findings, with a focus on concomitant Alzheimer pathology, in neuropathologically verified DLB cases.
METHODS:
The extent of neurofibrillary pathology (Braak stage), neuritic plaques (CERAD stage), Alzheimer pathology (PPAD9... (More) - OBJECTIVE:
The presence of concomitant Alzheimer pathology has been linked to earlier death in cases with dementia with Lewy bodies (DLB). Recently, elevated cerebrospinal fluid (CSF) tau protein levels have been reported to be associated with shorter survival in clinically diagnosed DLB. Correlations between CSF biomarkers and neuropathological findings in DLB are missing. The aim of this study was to investigate correlations between CSF biomarker levels and histopathological findings, with a focus on concomitant Alzheimer pathology, in neuropathologically verified DLB cases.
METHODS:
The extent of neurofibrillary pathology (Braak stage), neuritic plaques (CERAD stage), Alzheimer pathology (PPAD9 stage) and cerebral amyloid angiopathy was assessed in 16 cases with DLB in whom total tau (T-tau), hyperphosphorylated tau and amyloid beta 1-42 (Aβ42) protein levels in CSF had been analyzed in vivo. Demographic and clinical data were collected.
RESULTS:
Both Braak and PPAD9 stages were inversely correlated with Aβ42 levels, whereas CERAD stage showed no significant correlations. Cerebral amyloid angiopathy correlated positively with T-tau and T-tau/Aβ42 ratio, and inversely with Aβ42 levels, but the group showed a very heterogeneous extent of cerebral amyloid angiopathy.
CONCLUSIONS:
The burden of concomitant Alzheimer pathology correlates with CSF Aβ42 but not with T-tau levels in cases with neuropathologically defined DLB. Copyright © 2012 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3047326
- author
- Brunnström, Hans
LU
; Hansson, Oskar
LU
; Zetterberg, Henrik
; Londos, Elisabet
LU
and Englund, Elisabet
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Geriatric Psychiatry
- volume
- 28
- issue
- 7
- pages
- 738 - 744
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000319944200009
- pmid:22911491
- scopus:84878765032
- pmid:22911491
- ISSN
- 1099-1166
- DOI
- 10.1002/gps.3881
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Clinical Memory Research Unit (013242610), Pathology, (Lund) (013030000)
- id
- 4546ad94-33eb-4f25-8d0a-977cb3c45f21 (old id 3047326)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22911491?dopt=Abstract
- date added to LUP
- 2016-04-01 10:53:25
- date last changed
- 2022-03-27 20:31:48
@article{4546ad94-33eb-4f25-8d0a-977cb3c45f21,
abstract = {{OBJECTIVE: <br/><br>
The presence of concomitant Alzheimer pathology has been linked to earlier death in cases with dementia with Lewy bodies (DLB). Recently, elevated cerebrospinal fluid (CSF) tau protein levels have been reported to be associated with shorter survival in clinically diagnosed DLB. Correlations between CSF biomarkers and neuropathological findings in DLB are missing. The aim of this study was to investigate correlations between CSF biomarker levels and histopathological findings, with a focus on concomitant Alzheimer pathology, in neuropathologically verified DLB cases. <br/><br>
<br/><br>
METHODS: <br/><br>
The extent of neurofibrillary pathology (Braak stage), neuritic plaques (CERAD stage), Alzheimer pathology (PPAD9 stage) and cerebral amyloid angiopathy was assessed in 16 cases with DLB in whom total tau (T-tau), hyperphosphorylated tau and amyloid beta 1-42 (Aβ42) protein levels in CSF had been analyzed in vivo. Demographic and clinical data were collected. <br/><br>
<br/><br>
RESULTS: <br/><br>
Both Braak and PPAD9 stages were inversely correlated with Aβ42 levels, whereas CERAD stage showed no significant correlations. Cerebral amyloid angiopathy correlated positively with T-tau and T-tau/Aβ42 ratio, and inversely with Aβ42 levels, but the group showed a very heterogeneous extent of cerebral amyloid angiopathy. <br/><br>
<br/><br>
CONCLUSIONS: <br/><br>
The burden of concomitant Alzheimer pathology correlates with CSF Aβ42 but not with T-tau levels in cases with neuropathologically defined DLB. Copyright © 2012 John Wiley & Sons, Ltd.}},
author = {{Brunnström, Hans and Hansson, Oskar and Zetterberg, Henrik and Londos, Elisabet and Englund, Elisabet}},
issn = {{1099-1166}},
language = {{eng}},
number = {{7}},
pages = {{738--744}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Geriatric Psychiatry}},
title = {{Correlations of CSF tau and amyloid levels with Alzheimer pathology in neuropathologically verified dementia with Lewy bodies.}},
url = {{http://dx.doi.org/10.1002/gps.3881}},
doi = {{10.1002/gps.3881}},
volume = {{28}},
year = {{2013}},
}