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Waning predictive value of serum adiponectin for fracture risk in elderly men: MrOS Sweden

Johansson, H.; Oden, A.; Karlsson, Magnus LU ; McCloskey, E.; Kanis, J. A.; Ohlsson, C. and Mellstrom, D. (2014) In Osteoporosis International 25(7). p.1831-1836
Abstract
Serum adiponectin is a risk factor for fracture. The predictive value attenuates with time in elderly men so that its use for the risk assessment in the long term is questionable. The study underlines the importance of testing the long-term stability of potential risk factors. High serum adiponectin is associated with an increased risk of fracture in elderly men. The aim of the present study was to determine the impact of adiponectin on the probability of fracture as a function of time. The probability of osteoporotic fracture was computed in 989 elderly men from the MrOS study in Sweden. Baseline data included clinical risk factors for fracture, femoral neck BMD and serum adiponectin. Men were followed for up to 7.4 years with a mean... (More)
Serum adiponectin is a risk factor for fracture. The predictive value attenuates with time in elderly men so that its use for the risk assessment in the long term is questionable. The study underlines the importance of testing the long-term stability of potential risk factors. High serum adiponectin is associated with an increased risk of fracture in elderly men. The aim of the present study was to determine the impact of adiponectin on the probability of fracture as a function of time. The probability of osteoporotic fracture was computed in 989 elderly men from the MrOS study in Sweden. Baseline data included clinical risk factors for fracture, femoral neck BMD and serum adiponectin. Men were followed for up to 7.4 years with a mean follow up of 5.3 years (range 0.0-7.4 years). Poisson regression was used to model the hazard function for osteoporotic fracture and death to determine the 10 year probability of fracture. During follow up, 124 men sustained one or more osteoporotic fracture. There was a significant interaction between adiponectin and time since baseline (p = 0.026) such that the longer time since baseline, the lower the gradient of fracture risk. When using this interaction in the calculation of 10-year probability of fracture, the probabilities of osteoporotic fracture varied little over the range of adiponectin values. Serum adiponectin is a risk factor for fracture. Nevertheless, the predictive value attenuates with time so that its use for the risk assessment in the long term is questionable. This study underlines the importance of testing the long-term stability of potential risk factors that might be used in fracture risk assessment. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adiponectin, Elderly men, Probability of fracture, Osteoporotic fracture
in
Osteoporosis International
volume
25
issue
7
pages
1831 - 1836
publisher
Springer
external identifiers
  • wos:000337034600002
  • scopus:84902356906
ISSN
1433-2965
DOI
10.1007/s00198-014-2654-0
language
English
LU publication?
yes
id
d2496fd4-4bad-4789-919f-53c8f8065243 (old id 4549091)
date added to LUP
2014-08-01 07:37:34
date last changed
2017-04-30 11:37:48
@article{d2496fd4-4bad-4789-919f-53c8f8065243,
  abstract     = {Serum adiponectin is a risk factor for fracture. The predictive value attenuates with time in elderly men so that its use for the risk assessment in the long term is questionable. The study underlines the importance of testing the long-term stability of potential risk factors. High serum adiponectin is associated with an increased risk of fracture in elderly men. The aim of the present study was to determine the impact of adiponectin on the probability of fracture as a function of time. The probability of osteoporotic fracture was computed in 989 elderly men from the MrOS study in Sweden. Baseline data included clinical risk factors for fracture, femoral neck BMD and serum adiponectin. Men were followed for up to 7.4 years with a mean follow up of 5.3 years (range 0.0-7.4 years). Poisson regression was used to model the hazard function for osteoporotic fracture and death to determine the 10 year probability of fracture. During follow up, 124 men sustained one or more osteoporotic fracture. There was a significant interaction between adiponectin and time since baseline (p = 0.026) such that the longer time since baseline, the lower the gradient of fracture risk. When using this interaction in the calculation of 10-year probability of fracture, the probabilities of osteoporotic fracture varied little over the range of adiponectin values. Serum adiponectin is a risk factor for fracture. Nevertheless, the predictive value attenuates with time so that its use for the risk assessment in the long term is questionable. This study underlines the importance of testing the long-term stability of potential risk factors that might be used in fracture risk assessment.},
  author       = {Johansson, H. and Oden, A. and Karlsson, Magnus and McCloskey, E. and Kanis, J. A. and Ohlsson, C. and Mellstrom, D.},
  issn         = {1433-2965},
  keyword      = {Adiponectin,Elderly men,Probability of fracture,Osteoporotic fracture},
  language     = {eng},
  number       = {7},
  pages        = {1831--1836},
  publisher    = {Springer},
  series       = {Osteoporosis International},
  title        = {Waning predictive value of serum adiponectin for fracture risk in elderly men: MrOS Sweden},
  url          = {http://dx.doi.org/10.1007/s00198-014-2654-0},
  volume       = {25},
  year         = {2014},
}