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Language and mathematical problems as precursors of psychotic-like experiences and juvenile mania symptoms

Cederlof, M.; Ostberg, P.; Pettersson, E.; Anckarsäter, Henrik LU ; Gumpert, C.; Lundstrom, S. and Lichtenstein, P. (2014) In Psychological Medicine 44(6). p.1293-1302
Abstract
Background. Psychotic-like experiences (PLEs) and juvenile mania in adolescence index risk for severe psychopathology in adulthood. The importance of childhood problems with communication, reading, speech and mathematics for the development of PLEs and juvenile mania is not well understood. Method. Through the Child and Adolescent Twin Study in Sweden, we identified 5812 children. The parents were interviewed about their children's development at age 9 or 12 years. At age 15 or 18 years, children and parents completed questionnaires targeting current PLEs and juvenile mania symptoms. Logistic regressions were used to assess associations between problems with communication, reading, speech and mathematics and PLEs/juvenile mania symptoms.... (More)
Background. Psychotic-like experiences (PLEs) and juvenile mania in adolescence index risk for severe psychopathology in adulthood. The importance of childhood problems with communication, reading, speech and mathematics for the development of PLEs and juvenile mania is not well understood. Method. Through the Child and Adolescent Twin Study in Sweden, we identified 5812 children. The parents were interviewed about their children's development at age 9 or 12 years. At age 15 or 18 years, children and parents completed questionnaires targeting current PLEs and juvenile mania symptoms. Logistic regressions were used to assess associations between problems with communication, reading, speech and mathematics and PLEs/juvenile mania symptoms. To evaluate the relative importance of genes and environment in these associations, we used bivariate twin analyses based on structural equation models. Results. Children with parent-endorsed childhood problems with communication, reading and mathematics had an increased risk of developing auditory hallucinations and parental-reported juvenile mania symptoms in adolescence. The most consistent finding was that children with childhood problems with communication, reading and mathematics had an increased risk of developing auditory hallucinations [for example, the risk for self-reported auditory hallucinations at age 15 was increased by 96% for children with communication problems: OR (odds ratio) 1.96, 95% confidence interval (CI) 1.33-2.88]. The twin analyses showed that genetic effects accounted for the increased risk of PLEs and juvenile mania symptoms among children with communication problems. Conclusions. Childhood problems with communication, reading and mathematics predict PLEs and juvenile mania symptoms in adolescence. Similar to the case for schizophrenia and bipolar disorder, PLEs and juvenile mania may share genetic aetiological factors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Juvenile mania symptoms, language problems, mathematical problems, psychotic-like experiences
in
Psychological Medicine
volume
44
issue
6
pages
1293 - 1302
publisher
Cambridge University Press
external identifiers
  • wos:000336668700016
  • scopus:84922613357
ISSN
1469-8978
DOI
10.1017/S0033291713002018
language
English
LU publication?
yes
id
4f159386-de35-4e9c-a283-b47ff8fbe12c (old id 4558499)
date added to LUP
2014-08-01 07:40:14
date last changed
2017-11-12 03:06:10
@article{4f159386-de35-4e9c-a283-b47ff8fbe12c,
  abstract     = {Background. Psychotic-like experiences (PLEs) and juvenile mania in adolescence index risk for severe psychopathology in adulthood. The importance of childhood problems with communication, reading, speech and mathematics for the development of PLEs and juvenile mania is not well understood. Method. Through the Child and Adolescent Twin Study in Sweden, we identified 5812 children. The parents were interviewed about their children's development at age 9 or 12 years. At age 15 or 18 years, children and parents completed questionnaires targeting current PLEs and juvenile mania symptoms. Logistic regressions were used to assess associations between problems with communication, reading, speech and mathematics and PLEs/juvenile mania symptoms. To evaluate the relative importance of genes and environment in these associations, we used bivariate twin analyses based on structural equation models. Results. Children with parent-endorsed childhood problems with communication, reading and mathematics had an increased risk of developing auditory hallucinations and parental-reported juvenile mania symptoms in adolescence. The most consistent finding was that children with childhood problems with communication, reading and mathematics had an increased risk of developing auditory hallucinations [for example, the risk for self-reported auditory hallucinations at age 15 was increased by 96% for children with communication problems: OR (odds ratio) 1.96, 95% confidence interval (CI) 1.33-2.88]. The twin analyses showed that genetic effects accounted for the increased risk of PLEs and juvenile mania symptoms among children with communication problems. Conclusions. Childhood problems with communication, reading and mathematics predict PLEs and juvenile mania symptoms in adolescence. Similar to the case for schizophrenia and bipolar disorder, PLEs and juvenile mania may share genetic aetiological factors.},
  author       = {Cederlof, M. and Ostberg, P. and Pettersson, E. and Anckarsäter, Henrik and Gumpert, C. and Lundstrom, S. and Lichtenstein, P.},
  issn         = {1469-8978},
  keyword      = {Juvenile mania symptoms,language problems,mathematical problems,psychotic-like experiences},
  language     = {eng},
  number       = {6},
  pages        = {1293--1302},
  publisher    = {Cambridge University Press},
  series       = {Psychological Medicine},
  title        = {Language and mathematical problems as precursors of psychotic-like experiences and juvenile mania symptoms},
  url          = {http://dx.doi.org/10.1017/S0033291713002018},
  volume       = {44},
  year         = {2014},
}