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Treatment with a topical glucocorticoid, budesonide, reduced the variability of rhinomanometric nasal airway resistance

Thulesius, Helle L.; Cervin, Anders LU and Jessen, Max (2014) In Rhinology 52(1). p.19-24
Abstract
Background: Previous rhinomanometry studies have shown significant long-term variability of the nasal airway resistance and questioned the clinical validity of rhinomanonnetry. Research question: Could treatment with a topical glucocorticoid, budesonide, influence the long-term variability of active anterior rhinomanometry? Methods: Eight healthy volunteers participated in an unblinded controlled trial without, and later with, nasal budesonide once a day for 5 months. Their nasal airway resistance was measured every two weeks with active anterior rhinomanometry before and after decongestion with xylometazoline hydrochloride. In addition, subjective nasal obstruction was evaluated on a Visual Analogue Scale before each measurement.The... (More)
Background: Previous rhinomanometry studies have shown significant long-term variability of the nasal airway resistance and questioned the clinical validity of rhinomanonnetry. Research question: Could treatment with a topical glucocorticoid, budesonide, influence the long-term variability of active anterior rhinomanometry? Methods: Eight healthy volunteers participated in an unblinded controlled trial without, and later with, nasal budesonide once a day for 5 months. Their nasal airway resistance was measured every two weeks with active anterior rhinomanometry before and after decongestion with xylometazoline hydrochloride. In addition, subjective nasal obstruction was evaluated on a Visual Analogue Scale before each measurement.The participants had a year earlier been investigated with rhinomanometry every two weeks during 5 months but without budesonide treatment. We compared the variability of nasal airway resistance during the two periods with and without treatment with topical budesonide. Results: Budesonide significantly reduced mean nasal airway resistance and the standard deviation of the mean after decongestion for 6 of 8 participants. The mean reduction of the nasal airway resistance was 40% for the decongested nasal cavity compared to the period without treatment with nasal budesonide. Subjective nasal obstruction assessed by Visual Analogue Scale was reduced in 3 of the 8 participants. Conclusion: The variability of nasal airway resistance was significantly reduced by treatment with topical budesonide for 6 out of 8 healthy volunteers participating in an unblinded repeated 5 month trial where the participants served as their own controls. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
rhinomanometry, nasal airway resistance, topical nasal glucocorticoid, xylometazoline, budesonide
in
Rhinology
volume
52
issue
1
pages
19 - 24
publisher
International Rhinologic Society
external identifiers
  • wos:000336514900004
  • scopus:84897890998
ISSN
0300-0729
DOI
10.4193/Rhino12.180
language
English
LU publication?
yes
id
f0164114-a60a-4b76-90e2-348f743c656a (old id 4558509)
date added to LUP
2014-08-01 07:40:08
date last changed
2017-01-01 05:24:50
@article{f0164114-a60a-4b76-90e2-348f743c656a,
  abstract     = {Background: Previous rhinomanometry studies have shown significant long-term variability of the nasal airway resistance and questioned the clinical validity of rhinomanonnetry. Research question: Could treatment with a topical glucocorticoid, budesonide, influence the long-term variability of active anterior rhinomanometry? Methods: Eight healthy volunteers participated in an unblinded controlled trial without, and later with, nasal budesonide once a day for 5 months. Their nasal airway resistance was measured every two weeks with active anterior rhinomanometry before and after decongestion with xylometazoline hydrochloride. In addition, subjective nasal obstruction was evaluated on a Visual Analogue Scale before each measurement.The participants had a year earlier been investigated with rhinomanometry every two weeks during 5 months but without budesonide treatment. We compared the variability of nasal airway resistance during the two periods with and without treatment with topical budesonide. Results: Budesonide significantly reduced mean nasal airway resistance and the standard deviation of the mean after decongestion for 6 of 8 participants. The mean reduction of the nasal airway resistance was 40% for the decongested nasal cavity compared to the period without treatment with nasal budesonide. Subjective nasal obstruction assessed by Visual Analogue Scale was reduced in 3 of the 8 participants. Conclusion: The variability of nasal airway resistance was significantly reduced by treatment with topical budesonide for 6 out of 8 healthy volunteers participating in an unblinded repeated 5 month trial where the participants served as their own controls.},
  author       = {Thulesius, Helle L. and Cervin, Anders and Jessen, Max},
  issn         = {0300-0729},
  keyword      = {rhinomanometry,nasal airway resistance,topical nasal glucocorticoid,xylometazoline,budesonide},
  language     = {eng},
  number       = {1},
  pages        = {19--24},
  publisher    = {International Rhinologic Society},
  series       = {Rhinology},
  title        = {Treatment with a topical glucocorticoid, budesonide, reduced the variability of rhinomanometric nasal airway resistance},
  url          = {http://dx.doi.org/10.4193/Rhino12.180},
  volume       = {52},
  year         = {2014},
}