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Computer-aided diagnosis system outperforms scoring analysis in myocardial perfusion imaging

Johansson, Lena; Edenbrandt, Lars LU ; Nakajima, Kenichi; Lomsky, Milan; Svensson, Sven-Eric and Trägårdh, Elin LU (2014) In Journal of Nuclear Cardiology 21(3). p.416-423
Abstract
The aim of this myocardial perfusion imaging (MPI) study was to compare the diagnostic performance of two computer-aided diagnosis (CAD) systems, EXINI Heart(TM) (EXINI), and PERFEXTM (PERFEX) Emory Cardiac Toolbox (ECT), and the summed stress score (SSS) values from both software packages. We studied 1,052 consecutive patients who underwent 2-day stress/rest Tc-99m-sestamibi MPI studies. The reference standard classifications for the MPI studies were obtained from three experienced physicians who separately classified all cases regarding the presence or absence of ischemia and/or infarction. Automatic processing was carried out using EXINI and PERFEX to obtain CAD results and SSS values based on the 17-segment model. The three experts'... (More)
The aim of this myocardial perfusion imaging (MPI) study was to compare the diagnostic performance of two computer-aided diagnosis (CAD) systems, EXINI Heart(TM) (EXINI), and PERFEXTM (PERFEX) Emory Cardiac Toolbox (ECT), and the summed stress score (SSS) values from both software packages. We studied 1,052 consecutive patients who underwent 2-day stress/rest Tc-99m-sestamibi MPI studies. The reference standard classifications for the MPI studies were obtained from three experienced physicians who separately classified all cases regarding the presence or absence of ischemia and/or infarction. Automatic processing was carried out using EXINI and PERFEX to obtain CAD results and SSS values based on the 17-segment model. The three experts' classifications showed ischemia in 257 patients and abnormal studies, i.e., either ischemia or infarction or both, in 318 patients. Accuracy was significantly higher in EXINI than in PERFEX, regarding both the detection of ischemia (87.4 vs 77.6%; P < 0.0001) and the detection of abnormal studies (91.6 vs 67.9%; P < 0.0001). EXINI's CAD system showed a higher specificity than its SSS values (86.8 vs 73.6%; P < 0.0001) at the same level of sensitivity. EXINI demonstrated greater diagnostic accuracy for detection of ischemia and abnormal studies than did PERFEX. EXINI CAD also outperformed its SSS analysis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Ischemic heart disease, myocardial perfusion imaging, SPECT, automatic, quantification, software
in
Journal of Nuclear Cardiology
volume
21
issue
3
pages
416 - 423
publisher
Springer
external identifiers
  • wos:000336278000002
  • scopus:84901687743
ISSN
1532-6551
DOI
10.1007/s12350-013-9815-y
language
English
LU publication?
yes
id
ddb5237f-b93f-41c8-8bce-61a81d5f5461 (old id 4559009)
date added to LUP
2014-08-01 07:41:54
date last changed
2017-04-09 03:53:48
@article{ddb5237f-b93f-41c8-8bce-61a81d5f5461,
  abstract     = {The aim of this myocardial perfusion imaging (MPI) study was to compare the diagnostic performance of two computer-aided diagnosis (CAD) systems, EXINI Heart(TM) (EXINI), and PERFEXTM (PERFEX) Emory Cardiac Toolbox (ECT), and the summed stress score (SSS) values from both software packages. We studied 1,052 consecutive patients who underwent 2-day stress/rest Tc-99m-sestamibi MPI studies. The reference standard classifications for the MPI studies were obtained from three experienced physicians who separately classified all cases regarding the presence or absence of ischemia and/or infarction. Automatic processing was carried out using EXINI and PERFEX to obtain CAD results and SSS values based on the 17-segment model. The three experts' classifications showed ischemia in 257 patients and abnormal studies, i.e., either ischemia or infarction or both, in 318 patients. Accuracy was significantly higher in EXINI than in PERFEX, regarding both the detection of ischemia (87.4 vs 77.6%; P &lt; 0.0001) and the detection of abnormal studies (91.6 vs 67.9%; P &lt; 0.0001). EXINI's CAD system showed a higher specificity than its SSS values (86.8 vs 73.6%; P &lt; 0.0001) at the same level of sensitivity. EXINI demonstrated greater diagnostic accuracy for detection of ischemia and abnormal studies than did PERFEX. EXINI CAD also outperformed its SSS analysis.},
  author       = {Johansson, Lena and Edenbrandt, Lars and Nakajima, Kenichi and Lomsky, Milan and Svensson, Sven-Eric and Trägårdh, Elin},
  issn         = {1532-6551},
  keyword      = {Ischemic heart disease,myocardial perfusion imaging,SPECT,automatic,quantification,software},
  language     = {eng},
  number       = {3},
  pages        = {416--423},
  publisher    = {Springer},
  series       = {Journal of Nuclear Cardiology},
  title        = {Computer-aided diagnosis system outperforms scoring analysis in myocardial perfusion imaging},
  url          = {http://dx.doi.org/10.1007/s12350-013-9815-y},
  volume       = {21},
  year         = {2014},
}