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A novel cytotoxic terpenoid from the flowers of Kaunia lasiophthalma Griseb

Maldonado, Eliana LU ; Svensson, Daniel LU ; Oredsson, Stina LU and Sterner, Olov LU (2014) In Phytochemistry Letters 8. p.105-108
Abstract
A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is... (More)
A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is lacking selectivity as the MCF-10A cells were almost as sensitive. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Terpenoid, Structure elucidation, In vitro anticancer, Cytotoxicity
in
Phytochemistry Letters
volume
8
pages
105 - 108
publisher
Elsevier
external identifiers
  • wos:000335743300023
  • scopus:84896965503
ISSN
1874-3900
DOI
10.1016/j.phytol.2014.02.012
language
English
LU publication?
yes
id
6bc47bc7-b571-4b40-9eca-ac0a17b0c5df (old id 4559219)
date added to LUP
2014-07-17 14:45:30
date last changed
2017-07-23 03:32:44
@article{6bc47bc7-b571-4b40-9eca-ac0a17b0c5df,
  abstract     = {A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is lacking selectivity as the MCF-10A cells were almost as sensitive. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.},
  author       = {Maldonado, Eliana and Svensson, Daniel and Oredsson, Stina and Sterner, Olov},
  issn         = {1874-3900},
  keyword      = {Terpenoid,Structure elucidation,In vitro anticancer,Cytotoxicity},
  language     = {eng},
  pages        = {105--108},
  publisher    = {Elsevier},
  series       = {Phytochemistry Letters},
  title        = {A novel cytotoxic terpenoid from the flowers of Kaunia lasiophthalma Griseb},
  url          = {http://dx.doi.org/10.1016/j.phytol.2014.02.012},
  volume       = {8},
  year         = {2014},
}