A novel cytotoxic terpenoid from the flowers of Kaunia lasiophthalma Griseb
(2014) In Phytochemistry Letters 8. p.105-108- Abstract
- A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is... (More)
- A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is lacking selectivity as the MCF-10A cells were almost as sensitive. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4559219
- author
- Maldonado, Eliana LU ; Svensson, Daniel LU ; Oredsson, Stina LU and Sterner, Olov LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Terpenoid, Structure elucidation, In vitro anticancer, Cytotoxicity
- in
- Phytochemistry Letters
- volume
- 8
- pages
- 105 - 108
- publisher
- Elsevier
- external identifiers
-
- wos:000335743300023
- scopus:84896965503
- ISSN
- 1874-3900
- DOI
- 10.1016/j.phytol.2014.02.012
- language
- English
- LU publication?
- yes
- id
- 6bc47bc7-b571-4b40-9eca-ac0a17b0c5df (old id 4559219)
- date added to LUP
- 2016-04-01 11:12:58
- date last changed
- 2022-02-18 00:55:08
@article{6bc47bc7-b571-4b40-9eca-ac0a17b0c5df,
abstract = {{A phytochemical study of the flowers of Kaunia lasiophthalma G. (Asteraceae) yielded a novel triterpene (1) together with several known sesquiterpenoids. The structure of the new compound was elucidated by analysis of the spectroscopic data. The biosynthetic origin of 1 is proposed to be a dimerization of an oxidized derivative (3) of the germacrane sesquiterpene costunolide (2), also present in the flowers. The anticancer activity of 1 in the five breast cancer cell lines HCC1937, JIMT-1, L56Br-C1, MCF-7 and SK-BR-3 was compared with the cytotoxicity in the normal-like breast epithelial cell line MCF-10A. 1 exhibited high cytotoxicity in all investigated cancer cell lines with IC50 values ranging from 0.67 to 7.0 mu M, although it is lacking selectivity as the MCF-10A cells were almost as sensitive. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.}},
author = {{Maldonado, Eliana and Svensson, Daniel and Oredsson, Stina and Sterner, Olov}},
issn = {{1874-3900}},
keywords = {{Terpenoid; Structure elucidation; In vitro anticancer; Cytotoxicity}},
language = {{eng}},
pages = {{105--108}},
publisher = {{Elsevier}},
series = {{Phytochemistry Letters}},
title = {{A novel cytotoxic terpenoid from the flowers of Kaunia lasiophthalma Griseb}},
url = {{http://dx.doi.org/10.1016/j.phytol.2014.02.012}},
doi = {{10.1016/j.phytol.2014.02.012}},
volume = {{8}},
year = {{2014}},
}