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A1M, an extravascular tissue cleaning and housekeeping protein.

Åkerström, Bo LU and Gram, Magnus LU (2014) In Free Radical Biology & Medicine 74. p.274-282
Abstract
Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its physiological role remained unknown for a long time. A series of recent publications have demonstrated that A1M is a vital part of tissue housekeeping. A strongly electronegative free thiol group forms the structural basis of heme-binding, reductase, and radical-trapping properties. A rapid flow of liver-produced A1M through blood and extravascular compartments ensures clearing of biological fluids from heme and free radicals and repair of oxidative lesions. After binding, both the radicals and the A1M are electroneutral and therefore do not present any further oxidative stress to... (More)
Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its physiological role remained unknown for a long time. A series of recent publications have demonstrated that A1M is a vital part of tissue housekeeping. A strongly electronegative free thiol group forms the structural basis of heme-binding, reductase, and radical-trapping properties. A rapid flow of liver-produced A1M through blood and extravascular compartments ensures clearing of biological fluids from heme and free radicals and repair of oxidative lesions. After binding, both the radicals and the A1M are electroneutral and therefore do not present any further oxidative stress to tissues. The biological cleaning cycle is completed by glomerular filtration, renal degradation, and urinary excretion of A1M heavily modified by covalently linked radicals and heme groups. Based on its role as a tissue housekeeping cleaning factor, A1M constitutes a potential therapeutic drug candidate in treatment or prophylaxis of diseases or conditions that are associated with pathological oxidative stress elements. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Free Radical Biology & Medicine
volume
74
pages
274 - 282
publisher
Elsevier
external identifiers
  • pmid:25035076
  • wos:000341274100025
  • scopus:84905396927
ISSN
0891-5849
DOI
10.1016/j.freeradbiomed.2014.06.025
language
English
LU publication?
yes
id
4cde8651-b48f-4db3-8236-edae6ee47727 (old id 4582116)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25035076?dopt=Abstract
date added to LUP
2014-08-08 01:19:10
date last changed
2017-10-22 03:18:58
@article{4cde8651-b48f-4db3-8236-edae6ee47727,
  abstract     = {Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its physiological role remained unknown for a long time. A series of recent publications have demonstrated that A1M is a vital part of tissue housekeeping. A strongly electronegative free thiol group forms the structural basis of heme-binding, reductase, and radical-trapping properties. A rapid flow of liver-produced A1M through blood and extravascular compartments ensures clearing of biological fluids from heme and free radicals and repair of oxidative lesions. After binding, both the radicals and the A1M are electroneutral and therefore do not present any further oxidative stress to tissues. The biological cleaning cycle is completed by glomerular filtration, renal degradation, and urinary excretion of A1M heavily modified by covalently linked radicals and heme groups. Based on its role as a tissue housekeeping cleaning factor, A1M constitutes a potential therapeutic drug candidate in treatment or prophylaxis of diseases or conditions that are associated with pathological oxidative stress elements.},
  author       = {Åkerström, Bo and Gram, Magnus},
  issn         = {0891-5849},
  language     = {eng},
  pages        = {274--282},
  publisher    = {Elsevier},
  series       = {Free Radical Biology & Medicine},
  title        = {A1M, an extravascular tissue cleaning and housekeeping protein.},
  url          = {http://dx.doi.org/10.1016/j.freeradbiomed.2014.06.025},
  volume       = {74},
  year         = {2014},
}