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The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer.

Jansson, Sara LU ; Bendahl, Pär-Ola LU ; Grabau, Dorthe LU ; Falck, Anna-Karin LU ; Fernö, Mårten LU ; Aaltonen, Kristina LU and Rydén, Lisa LU orcid (2014) In PLoS ONE 9(7).
Abstract
Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 and PDGFRα, their gene copy number, and prognosis in TNBC compared to non-TNBC.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
7
article number
e102176
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:25025175
  • wos:000339992400048
  • scopus:84904268803
  • pmid:25025175
ISSN
1932-6203
DOI
10.1371/journal.pone.0102176
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Surgery (Lund) (013009000), Pathology, (Lund) (013030000), Oncology, MV (013035000)
id
eefddef8-f276-4759-8983-20aea091ebd0 (old id 4582246)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25025175?dopt=Abstract
date added to LUP
2016-04-01 13:41:20
date last changed
2021-09-15 05:22:38
@article{eefddef8-f276-4759-8983-20aea091ebd0,
  abstract     = {Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 and PDGFRα, their gene copy number, and prognosis in TNBC compared to non-TNBC.},
  author       = {Jansson, Sara and Bendahl, Pär-Ola and Grabau, Dorthe and Falck, Anna-Karin and Fernö, Mårten and Aaltonen, Kristina and Rydén, Lisa},
  issn         = {1932-6203},
  language     = {eng},
  number       = {7},
  publisher    = {Public Library of Science (PLoS)},
  series       = {PLoS ONE},
  title        = {The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer.},
  url          = {https://lup.lub.lu.se/search/files/3532956/5154500.pdf},
  doi          = {10.1371/journal.pone.0102176},
  volume       = {9},
  year         = {2014},
}