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The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer.

Jansson, Sara LU ; Bendahl, Pär-Ola LU ; Grabau, Dorthe LU ; Falck, Anna-Karin LU ; Fernö, Mårten LU ; Aaltonen, Kristina LU and Rydén, Lisa LU (2014) In PLoS ONE 9(7).
Abstract
Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 and PDGFRα, their gene copy number, and prognosis in TNBC compared to non-TNBC.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
9
issue
7
publisher
Public Library of Science
external identifiers
  • pmid:25025175
  • wos:000339992400048
  • scopus:84904268803
ISSN
1932-6203
DOI
10.1371/journal.pone.0102176
language
English
LU publication?
yes
id
eefddef8-f276-4759-8983-20aea091ebd0 (old id 4582246)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25025175?dopt=Abstract
date added to LUP
2014-08-08 00:17:07
date last changed
2017-11-05 04:00:50
@article{eefddef8-f276-4759-8983-20aea091ebd0,
  abstract     = {Triple-negative breast cancer (TNBC) is a heterogeneous subgroup of breast cancer with poor prognosis and no targeted therapy available. Receptor tyrosine kinases (RTKs) are emerging targets in anticancer therapy and many RTK-inhibiting drugs are currently being developed. The aim of this study was to elucidate if there is a correlation between the protein expression of three RTKs c-KIT, VEGFR2 and PDGFRα, their gene copy number, and prognosis in TNBC compared to non-TNBC.},
  articleno    = {e102176},
  author       = {Jansson, Sara and Bendahl, Pär-Ola and Grabau, Dorthe and Falck, Anna-Karin and Fernö, Mårten and Aaltonen, Kristina and Rydén, Lisa},
  issn         = {1932-6203},
  language     = {eng},
  number       = {7},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {The Three Receptor Tyrosine Kinases c-KIT, VEGFR2 and PDGFRα, Closely Spaced at 4q12, Show Increased Protein Expression in Triple-Negative Breast Cancer.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0102176},
  volume       = {9},
  year         = {2014},
}