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Increased Levels of Hyaluronic Acid in Cerebrospinal Fluid in Patients with Vascular Dementia.

Nägga, Katarina LU ; Hansson, Oskar LU ; van Westen, Danielle LU ; Minthon, Lennart LU and Wennström, Malin LU (2014) In Journal of Alzheimer's Disease 42(4). p.1435-1441
Abstract
Hyaluronic acid (HA) has been shown to affect angiogenesis and the function of the blood-brain barrier, and a crucial role for HA in atherosclerosis has been described. We have recently demonstrated changes in the levels of HA in cerebrospinal fluid (CSF) in patients with Alzheimer's disease (AD) with documented vascular alterations. To further investigate if the level of HA in CSF can be used as a clinical diagnostic biomarker to identify vascular pathology in dementia, we analyzed the levels of HA in the CSF of patients with vascular dementia (VaD) (n = 46), AD (n = 45), and controls without dementia (n = 26). In line with our previous data, we found significantly increased levels of HA in CSF from patients with VaD compared with... (More)
Hyaluronic acid (HA) has been shown to affect angiogenesis and the function of the blood-brain barrier, and a crucial role for HA in atherosclerosis has been described. We have recently demonstrated changes in the levels of HA in cerebrospinal fluid (CSF) in patients with Alzheimer's disease (AD) with documented vascular alterations. To further investigate if the level of HA in CSF can be used as a clinical diagnostic biomarker to identify vascular pathology in dementia, we analyzed the levels of HA in the CSF of patients with vascular dementia (VaD) (n = 46), AD (n = 45), and controls without dementia (n = 26). In line with our previous data, we found significantly increased levels of HA in CSF from patients with VaD compared with controls, whereas the levels of HA in patients with AD were found to be unaltered compared with controls and patients with VaD. We also detected increased levels of HA in individuals with vascular changes determined as significant white matter changes or previous infarction on cranial computed tomography or magnetic resonance imaging, compared with individuals without these findings. Furthermore, we found a significant positive correlation between the levels of HA and the CSF/serum albumin ratio, an indicator of blood-brain barrier integrity, in patients with VaD and AD, supporting the role of HA in vascular changes in the brain. Our results indicate a potential diagnostic value for the detection of vascular brain changes in dementia using CSF levels of HA, but emphasize the importance of further development of more sensitive HA assays. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Alzheimer's Disease
volume
42
issue
4
pages
1435 - 1441
publisher
IOS Press
external identifiers
  • pmid:25024336
  • wos:000343763000028
  • scopus:84907972736
ISSN
1387-2877
DOI
10.3233/JAD-141200
language
English
LU publication?
yes
id
b5053733-97e5-4e50-b6ec-47d2f3cffb8d (old id 4582283)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25024336?dopt=Abstract
date added to LUP
2014-08-07 23:35:46
date last changed
2017-09-17 03:19:28
@article{b5053733-97e5-4e50-b6ec-47d2f3cffb8d,
  abstract     = {Hyaluronic acid (HA) has been shown to affect angiogenesis and the function of the blood-brain barrier, and a crucial role for HA in atherosclerosis has been described. We have recently demonstrated changes in the levels of HA in cerebrospinal fluid (CSF) in patients with Alzheimer's disease (AD) with documented vascular alterations. To further investigate if the level of HA in CSF can be used as a clinical diagnostic biomarker to identify vascular pathology in dementia, we analyzed the levels of HA in the CSF of patients with vascular dementia (VaD) (n = 46), AD (n = 45), and controls without dementia (n = 26). In line with our previous data, we found significantly increased levels of HA in CSF from patients with VaD compared with controls, whereas the levels of HA in patients with AD were found to be unaltered compared with controls and patients with VaD. We also detected increased levels of HA in individuals with vascular changes determined as significant white matter changes or previous infarction on cranial computed tomography or magnetic resonance imaging, compared with individuals without these findings. Furthermore, we found a significant positive correlation between the levels of HA and the CSF/serum albumin ratio, an indicator of blood-brain barrier integrity, in patients with VaD and AD, supporting the role of HA in vascular changes in the brain. Our results indicate a potential diagnostic value for the detection of vascular brain changes in dementia using CSF levels of HA, but emphasize the importance of further development of more sensitive HA assays.},
  author       = {Nägga, Katarina and Hansson, Oskar and van Westen, Danielle and Minthon, Lennart and Wennström, Malin},
  issn         = {1387-2877},
  language     = {eng},
  number       = {4},
  pages        = {1435--1441},
  publisher    = {IOS Press},
  series       = {Journal of Alzheimer's Disease},
  title        = {Increased Levels of Hyaluronic Acid in Cerebrospinal Fluid in Patients with Vascular Dementia.},
  url          = {http://dx.doi.org/10.3233/JAD-141200},
  volume       = {42},
  year         = {2014},
}