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The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.

Jakubowski, Joseph A; Angiolillo, Dominick J; Zhou, Chunmei; Small, David S; Moser, Brian A; Ten Berg, Jurrien M; Brown, Patricia B; James, Stefan; Winters, Kenneth J and Erlinge, David LU (2014) In Thrombosis Research 134(3). p.552-557
Abstract
Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis Research
volume
134
issue
3
pages
552 - 557
external identifiers
  • pmid:25022828
  • wos:000341310000006
  • scopus:84903871881
ISSN
1879-2472
DOI
10.1016/j.thromres.2014.05.019
language
English
LU publication?
yes
id
27c8e49b-b3d7-4f33-9993-934e594d1e5d (old id 4582351)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25022828?dopt=Abstract
date added to LUP
2014-08-07 23:15:08
date last changed
2017-05-14 03:19:55
@article{27c8e49b-b3d7-4f33-9993-934e594d1e5d,
  abstract     = {Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.},
  author       = {Jakubowski, Joseph A and Angiolillo, Dominick J and Zhou, Chunmei and Small, David S and Moser, Brian A and Ten Berg, Jurrien M and Brown, Patricia B and James, Stefan and Winters, Kenneth J and Erlinge, David},
  issn         = {1879-2472},
  language     = {eng},
  number       = {3},
  pages        = {552--557},
  series       = {Thrombosis Research},
  title        = {The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.},
  url          = {http://dx.doi.org/10.1016/j.thromres.2014.05.019},
  volume       = {134},
  year         = {2014},
}