The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.
(2014) In Thrombosis Research 134(3). p.552-557- Abstract
- Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4582351
- author
- Jakubowski, Joseph A
; Angiolillo, Dominick J
; Zhou, Chunmei
; Small, David S
; Moser, Brian A
; Ten Berg, Jurrien M
; Brown, Patricia B
; James, Stefan
; Winters, Kenneth J
and Erlinge, David
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Thrombosis Research
- volume
- 134
- issue
- 3
- pages
- 552 - 557
- publisher
- Elsevier
- external identifiers
-
- pmid:25022828
- wos:000341310000006
- pmid:25022828
- scopus:85027922782
- ISSN
- 1879-2472
- DOI
- 10.1016/j.thromres.2014.05.019
- language
- English
- LU publication?
- yes
- id
- 27c8e49b-b3d7-4f33-9993-934e594d1e5d (old id 4582351)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25022828?dopt=Abstract
- date added to LUP
- 2016-04-01 11:00:19
- date last changed
- 2022-04-28 03:41:58
@article{27c8e49b-b3d7-4f33-9993-934e594d1e5d, abstract = {{Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.}}, author = {{Jakubowski, Joseph A and Angiolillo, Dominick J and Zhou, Chunmei and Small, David S and Moser, Brian A and Ten Berg, Jurrien M and Brown, Patricia B and James, Stefan and Winters, Kenneth J and Erlinge, David}}, issn = {{1879-2472}}, language = {{eng}}, number = {{3}}, pages = {{552--557}}, publisher = {{Elsevier}}, series = {{Thrombosis Research}}, title = {{The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.}}, url = {{http://dx.doi.org/10.1016/j.thromres.2014.05.019}}, doi = {{10.1016/j.thromres.2014.05.019}}, volume = {{134}}, year = {{2014}}, }