Immunizations with unmodified tumor cells and simultaneous COX-2 inhibition eradicate malignant rat brain tumors and induce a long-lasting CD8(+) T cell memory.
Eberstål, Sofia LU ; Fritzell, Sara LU ; Sandén, Emma LU ; Visse, Edward LU ; Darabi, Anna LU and Siesjö, Peter LU
(2014)
In Journal of Neuroimmunology
274(1-2).
p.161-167
- Abstract
- Malignant brain tumors induce pronounced immunosuppression, which diminishes immune responses generated by immunotherapy. Here we report that peripheral immunotherapy, using irradiated unmodified whole tumor cells, and systemic cyclooxygenase-2 inhibition induce cure in glioma-bearing rats (60% cure rate), whereas neither monotherapy was sufficient to cure any animal. Moreover, the combined therapy protected against secondary tumor challenges (89% cure rate) and the secondary immune response was correlated with increased plasma interferon-gamma levels and CD8(+) T cells systemically and intratumorally. In conclusion, we demonstrate that cyclooxygenase-2 inhibition is sufficient to render unmodified tumor cells immunogenic in immunotherapy... (More)
- Malignant brain tumors induce pronounced immunosuppression, which diminishes immune responses generated by immunotherapy. Here we report that peripheral immunotherapy, using irradiated unmodified whole tumor cells, and systemic cyclooxygenase-2 inhibition induce cure in glioma-bearing rats (60% cure rate), whereas neither monotherapy was sufficient to cure any animal. Moreover, the combined therapy protected against secondary tumor challenges (89% cure rate) and the secondary immune response was correlated with increased plasma interferon-gamma levels and CD8(+) T cells systemically and intratumorally. In conclusion, we demonstrate that cyclooxygenase-2 inhibition is sufficient to render unmodified tumor cells immunogenic in immunotherapy of experimental brain tumors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4582364
- author
- Eberstål, Sofia
LU
; Fritzell, Sara
LU
; Sandén, Emma
LU
; Visse, Edward
LU
; Darabi, Anna
LU
and Siesjö, Peter
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Neuroimmunology
- volume
- 274
- issue
- 1-2
- pages
- 161 - 167
- publisher
- Elsevier
- external identifiers
-
- pmid:25022336
- wos:000342871600020
- scopus:84906939281
- pmid:25022336
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2014.06.019
- language
- English
- LU publication?
- yes
- id
- eaaced2f-8f21-4918-9f7c-aa85d4ea537e (old id 4582364)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25022336?dopt=Abstract
- date added to LUP
- 2016-04-01 10:06:37
- date last changed
- 2022-01-25 19:51:25
@article{eaaced2f-8f21-4918-9f7c-aa85d4ea537e,
abstract = {{Malignant brain tumors induce pronounced immunosuppression, which diminishes immune responses generated by immunotherapy. Here we report that peripheral immunotherapy, using irradiated unmodified whole tumor cells, and systemic cyclooxygenase-2 inhibition induce cure in glioma-bearing rats (60% cure rate), whereas neither monotherapy was sufficient to cure any animal. Moreover, the combined therapy protected against secondary tumor challenges (89% cure rate) and the secondary immune response was correlated with increased plasma interferon-gamma levels and CD8(+) T cells systemically and intratumorally. In conclusion, we demonstrate that cyclooxygenase-2 inhibition is sufficient to render unmodified tumor cells immunogenic in immunotherapy of experimental brain tumors.}},
author = {{Eberstål, Sofia and Fritzell, Sara and Sandén, Emma and Visse, Edward and Darabi, Anna and Siesjö, Peter}},
issn = {{1872-8421}},
language = {{eng}},
number = {{1-2}},
pages = {{161--167}},
publisher = {{Elsevier}},
series = {{Journal of Neuroimmunology}},
title = {{Immunizations with unmodified tumor cells and simultaneous COX-2 inhibition eradicate malignant rat brain tumors and induce a long-lasting CD8(+) T cell memory.}},
url = {{http://dx.doi.org/10.1016/j.jneuroim.2014.06.019}},
doi = {{10.1016/j.jneuroim.2014.06.019}},
volume = {{274}},
year = {{2014}},
}