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Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink

Spinelli, L.; Botwicz, M.; Zolek, N.; Kacprzak, M.; Milej, D.; Sawosz, P.; Liebert, A.; Weigel, U.; Durduran, T. and Foschum, F., et al. (2014) In Biomedical Optics Express 5(7). p.2037-2053
Abstract
A multi-center study has been set up to accurately characterize the optical properties of diffusive liquid phantoms based on Intralipid and India ink at near-infrared (NIR) wavelengths. Nine research laboratories from six countries adopting different measurement techniques, instrumental set-ups, and data analysis methods determined at their best the optical properties and relative uncertainties of diffusive dilutions prepared with common samples of the two compounds. By exploiting a suitable statistical model, comprehensive reference values at three NIR wavelengths for the intrinsic absorption coefficient of India ink and the intrinsic reduced scattering coefficient of Intralipid-20% were determined with an uncertainty of about 2% or... (More)
A multi-center study has been set up to accurately characterize the optical properties of diffusive liquid phantoms based on Intralipid and India ink at near-infrared (NIR) wavelengths. Nine research laboratories from six countries adopting different measurement techniques, instrumental set-ups, and data analysis methods determined at their best the optical properties and relative uncertainties of diffusive dilutions prepared with common samples of the two compounds. By exploiting a suitable statistical model, comprehensive reference values at three NIR wavelengths for the intrinsic absorption coefficient of India ink and the intrinsic reduced scattering coefficient of Intralipid-20% were determined with an uncertainty of about 2% or better, depending on the wavelength considered, and 1%, respectively. Even if in this study we focused on particular batches of India ink and Intralipid, the reference values determined here represent a solid and useful starting point for preparing diffusive liquid phantoms with accurately defined optical properties. Furthermore, due to the ready availability, low cost, long-term stability and batch-to-batch reproducibility of these compounds, they provide a unique fundamental tool for the calibration and performance assessment of diffuse optical spectroscopy instrumentation intended to be used in laboratory or clinical environment. Finally, the collaborative work presented here demonstrates that the accuracy level attained in this work for optical properties of diffusive phantoms is reliable. (C) 2014 Optical Society of America (Less)
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Biomedical Optics Express
volume
5
issue
7
pages
2037 - 2053
publisher
Optical Society of America
external identifiers
  • pmid:25071947
  • wos:000338929100005
  • scopus:84903729137
ISSN
2156-7085
DOI
10.1364/BOE.5.002037
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English
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797afac1-97d2-49d6-95f8-79ba5470208f (old id 4595751)
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2014-09-03 10:07:32
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@article{797afac1-97d2-49d6-95f8-79ba5470208f,
  abstract     = {A multi-center study has been set up to accurately characterize the optical properties of diffusive liquid phantoms based on Intralipid and India ink at near-infrared (NIR) wavelengths. Nine research laboratories from six countries adopting different measurement techniques, instrumental set-ups, and data analysis methods determined at their best the optical properties and relative uncertainties of diffusive dilutions prepared with common samples of the two compounds. By exploiting a suitable statistical model, comprehensive reference values at three NIR wavelengths for the intrinsic absorption coefficient of India ink and the intrinsic reduced scattering coefficient of Intralipid-20% were determined with an uncertainty of about 2% or better, depending on the wavelength considered, and 1%, respectively. Even if in this study we focused on particular batches of India ink and Intralipid, the reference values determined here represent a solid and useful starting point for preparing diffusive liquid phantoms with accurately defined optical properties. Furthermore, due to the ready availability, low cost, long-term stability and batch-to-batch reproducibility of these compounds, they provide a unique fundamental tool for the calibration and performance assessment of diffuse optical spectroscopy instrumentation intended to be used in laboratory or clinical environment. Finally, the collaborative work presented here demonstrates that the accuracy level attained in this work for optical properties of diffusive phantoms is reliable. (C) 2014 Optical Society of America},
  author       = {Spinelli, L. and Botwicz, M. and Zolek, N. and Kacprzak, M. and Milej, D. and Sawosz, P. and Liebert, A. and Weigel, U. and Durduran, T. and Foschum, F. and Kienle, A. and Baribeau, F. and Leclair, S. and Bouchard, J-P and Noiseux, I. and Gallant, P. and Mermut, O. and Farina, A. and Pifferi, A. and Torricelli, A. and Cubeddu, R. and Ho, H-C and Mazurenka, M. and Wabnitz, H. and Klauenberg, K. and Bodnar, O. and Elster, C. and Benazech-Lavoue, M. and Berube-Lauziere, Y. and Lesage, F. and Khoptyar, Dmitry and Subash, Arman and Andersson-Engels, Stefan and Di Ninni, P. and Martelli, F. and Zaccanti, G.},
  issn         = {2156-7085},
  language     = {eng},
  number       = {7},
  pages        = {2037--2053},
  publisher    = {Optical Society of America},
  series       = {Biomedical Optics Express},
  title        = {Determination of reference values for optical properties of liquid phantoms based on Intralipid and India ink},
  url          = {http://dx.doi.org/10.1364/BOE.5.002037},
  volume       = {5},
  year         = {2014},
}