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Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study

Lee, Hye-Seung; Burkhardt, Brant R.; McLeod, Wendy; Smith, Susan; Eberhard, Chris; Lynch, Kristian; Hadley, David; Rewers, Marian; Simell, Olli and She, Jin-Xiong, et al. (2014) In Diabetes/Metabolism Research Reviews 30(5). p.424-434
Abstract
Aims The Environmental Determinants of Diabetes in the Young planned biomarker discovery studies on longitudinal samples for persistent confirmed islet cell autoantibodies and type 1 diabetes using dietary biomarkers, metabolomics, microbiome/viral metagenomics and gene expression. Methods This article describes the details of planning The Environmental Determinants of Diabetes in the Young biomarker discovery studies using a nested case-control design that was chosen as an alternative to the full cohort analysis. In the frame of a nested case-control design, it guides the choice of matching factors, selection of controls, preparation of external quality control samples and reduction of batch effects along with proper sample allocation.... (More)
Aims The Environmental Determinants of Diabetes in the Young planned biomarker discovery studies on longitudinal samples for persistent confirmed islet cell autoantibodies and type 1 diabetes using dietary biomarkers, metabolomics, microbiome/viral metagenomics and gene expression. Methods This article describes the details of planning The Environmental Determinants of Diabetes in the Young biomarker discovery studies using a nested case-control design that was chosen as an alternative to the full cohort analysis. In the frame of a nested case-control design, it guides the choice of matching factors, selection of controls, preparation of external quality control samples and reduction of batch effects along with proper sample allocation. Results and conclusion Our design is to reduce potential bias and retain study power while reducing the costs by limiting the numbers of samples requiring laboratory analyses. It also covers two primary end points (the occurrence of diabetes-related autoantibodies and the diagnosis of type 1 diabetes). The resulting list of case-control matched samples for each laboratory was augmented with external quality control samples. Copyright (C) 2013 John Wiley & Sons, Ltd. (Less)
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published
subject
keywords
batch effects, biomarker discovery, nested case-control design, TEDDY, type 1 diabetes
in
Diabetes/Metabolism Research Reviews
volume
30
issue
5
pages
424 - 434
publisher
John Wiley & Sons
external identifiers
  • wos:000339416900009
  • scopus:84903691108
ISSN
1520-7552
DOI
10.1002/dmrr.2510
language
English
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yes
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6059356c-b7fd-44ff-b74c-d793b0990e6c (old id 4595789)
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2014-09-05 13:21:04
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2017-10-01 03:00:09
@article{6059356c-b7fd-44ff-b74c-d793b0990e6c,
  abstract     = {Aims The Environmental Determinants of Diabetes in the Young planned biomarker discovery studies on longitudinal samples for persistent confirmed islet cell autoantibodies and type 1 diabetes using dietary biomarkers, metabolomics, microbiome/viral metagenomics and gene expression. Methods This article describes the details of planning The Environmental Determinants of Diabetes in the Young biomarker discovery studies using a nested case-control design that was chosen as an alternative to the full cohort analysis. In the frame of a nested case-control design, it guides the choice of matching factors, selection of controls, preparation of external quality control samples and reduction of batch effects along with proper sample allocation. Results and conclusion Our design is to reduce potential bias and retain study power while reducing the costs by limiting the numbers of samples requiring laboratory analyses. It also covers two primary end points (the occurrence of diabetes-related autoantibodies and the diagnosis of type 1 diabetes). The resulting list of case-control matched samples for each laboratory was augmented with external quality control samples. Copyright (C) 2013 John Wiley & Sons, Ltd.},
  author       = {Lee, Hye-Seung and Burkhardt, Brant R. and McLeod, Wendy and Smith, Susan and Eberhard, Chris and Lynch, Kristian and Hadley, David and Rewers, Marian and Simell, Olli and She, Jin-Xiong and Hagopian, Bill and Lernmark, Åke and Akolkar, Beena and Ziegler, Anette G. and Krischer, Jeffrey P.},
  issn         = {1520-7552},
  keyword      = {batch effects,biomarker discovery,nested case-control design,TEDDY,type 1 diabetes},
  language     = {eng},
  number       = {5},
  pages        = {424--434},
  publisher    = {John Wiley & Sons},
  series       = {Diabetes/Metabolism Research Reviews},
  title        = {Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study},
  url          = {http://dx.doi.org/10.1002/dmrr.2510},
  volume       = {30},
  year         = {2014},
}