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Role of the DNA damage response in human papillomavirus RNA splicing and polyadenylation

Nilsson, Kersti LU ; Wu, Chengjun LU and Schwartz, Stefan LU (2018) In International Journal of Molecular Sciences 19(6).
Abstract

Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is activated. Recent research has shown that the DDR factors also interact with RNA binding proteins and affects RNA processing. DDR factors activated by DNA damage and that associate with HPV DNA can recruit splicing factors and RNA binding proteins to the HPV DNA and induce HPV late gene expression. This induction is the result of altered... (More)

Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is activated. Recent research has shown that the DDR factors also interact with RNA binding proteins and affects RNA processing. DDR factors activated by DNA damage and that associate with HPV DNA can recruit splicing factors and RNA binding proteins to the HPV DNA and induce HPV late gene expression. This induction is the result of altered alternative polyadenylation and splicing of HPV messenger RNA (mRNA). HPV uses the DDR machinery to replicate its DNA genome and to activate HPV late gene expression at the level of RNA processing.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
BCLAF1, BRCA1, DDR, HnRNP C, Papillomavirus, Polyadenylation, Splicing, SR proteins, TRAP150, U2AF65
in
International Journal of Molecular Sciences
volume
19
issue
6
publisher
MOLECULAR DIVERSITY PRESERVATION INT
external identifiers
  • scopus:85048588666
ISSN
1661-6596
DOI
10.3390/ijms19061735
language
English
LU publication?
yes
id
45b02138-d2d3-4389-9353-62e5d30b1c11
date added to LUP
2018-06-29 11:02:37
date last changed
2018-11-21 21:40:34
@article{45b02138-d2d3-4389-9353-62e5d30b1c11,
  abstract     = {<p>Human papillomaviruses (HPVs) have evolved to use the DNA repair machinery to replicate its DNA genome in differentiated cells. HPV activates the DNA damage response (DDR) in infected cells. Cellular DDR factors are recruited to the HPV DNA genome and position the cellular DNA polymerase on the HPV DNA and progeny genomes are synthesized. Following HPV DNA replication, HPV late gene expression is activated. Recent research has shown that the DDR factors also interact with RNA binding proteins and affects RNA processing. DDR factors activated by DNA damage and that associate with HPV DNA can recruit splicing factors and RNA binding proteins to the HPV DNA and induce HPV late gene expression. This induction is the result of altered alternative polyadenylation and splicing of HPV messenger RNA (mRNA). HPV uses the DDR machinery to replicate its DNA genome and to activate HPV late gene expression at the level of RNA processing.</p>},
  articleno    = {1735},
  author       = {Nilsson, Kersti and Wu, Chengjun and Schwartz, Stefan},
  issn         = {1661-6596},
  keyword      = {BCLAF1,BRCA1,DDR,HnRNP C,Papillomavirus,Polyadenylation,Splicing,SR proteins,TRAP150,U2AF65},
  language     = {eng},
  month        = {06},
  number       = {6},
  publisher    = {MOLECULAR DIVERSITY PRESERVATION INT},
  series       = {International Journal of Molecular Sciences},
  title        = {Role of the DNA damage response in human papillomavirus RNA splicing and polyadenylation},
  url          = {http://dx.doi.org/10.3390/ijms19061735},
  volume       = {19},
  year         = {2018},
}