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Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition.

Merritt, Melissa A; Riboli, Elio; Weiderpass, Elisabete; Tsilidis, Konstantinos K; Overvad, Kim; Tjønneland, Anne; Hansen, Louise; Dossus, Laure; Fagherazzi, Guy and Baglietto, Laura, et al. (2014) In Cancer Epidemiology 38(5). p.528-537
Abstract
There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased... (More)
There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development. (Less)
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Cancer Epidemiology
volume
38
issue
5
pages
528 - 537
publisher
Elsevier
external identifiers
  • pmid:25155210
  • wos:000346503300010
  • scopus:84908075396
ISSN
1877-7821
DOI
10.1016/j.canep.2014.07.011
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English
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cf91ee1e-44d2-48b9-96e6-83df0999dbd4 (old id 4613958)
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http://www.ncbi.nlm.nih.gov/pubmed/25155210?dopt=Abstract
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2014-09-09 17:30:14
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2017-05-21 03:14:57
@article{cf91ee1e-44d2-48b9-96e6-83df0999dbd4,
  abstract     = {There are inconsistent and limited data available to assess the relationship between fat intake and risk of epithelial ovarian cancer (EOC). We examined the consumption of total fat, fat sources and fat subtypes in relation to risk of EOC and its major histologic subtypes in the European Prospective Investigation into Cancer and Nutrition which includes incident invasive (n=1095) and borderline (n=96) EOC. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In multivariate models, we observed no association with consumption of total fat, animal or plant fat, saturated fat, cholesterol, monounsaturated fat, or fatty fish and risk of invasive EOC. There was, however, an increased risk of invasive EOC in the highest category of intake (Quartile 4 vs. Quartile 1) of polyunsaturated fat (HR=1.22, 95% CI=1.02-1.48, Ptrend=0.02). We did not observe heterogeneity in the risk associations in comparisons of serous and endometrioid histologic subtypes. This study does not support an etiological role for total fat intake in relation to EOC risk; however, based on observations of a positive association between intake of polyunsaturated fat and invasive EOC risk in the current and previous studies, this fat subtype warrants further investigation to determine its potential role in EOC development.},
  author       = {Merritt, Melissa A and Riboli, Elio and Weiderpass, Elisabete and Tsilidis, Konstantinos K and Overvad, Kim and Tjønneland, Anne and Hansen, Louise and Dossus, Laure and Fagherazzi, Guy and Baglietto, Laura and Fortner, Renée T and Ose, Jennifer and Steffen, Annika and Boeing, Heiner and Trichopoulou, Antonia and Trichopoulos, Dimitrios and Lagiou, Pagona and Masala, Giovanna and Sieri, Sabina and Mattiello, Amalia and Tumino, Rosario and Sacerdote, Carlotta and Bueno-de-Mesquita, H B As and Onland-Moret, N Charlotte and Peeters, Petra H and Hjartåker, Anette and Gram, Inger Torhild and Quirós, J Ramón and Obón-Santacana, Mireia and Molina-Montes, Esther and Huerta Castaño, José María and Ardanaz, Eva and Chamosa, Saioa and Sonestedt, Emily and Idahl, Annika and Lundin, Eva and Khaw, Kay-Tee and Wareham, Nicholas and Travis, Ruth C and Rinaldi, Sabina and Romieu, Isabelle and Chajes, Veronique and Gunter, Marc J},
  issn         = {1877-7821},
  language     = {eng},
  number       = {5},
  pages        = {528--537},
  publisher    = {Elsevier},
  series       = {Cancer Epidemiology},
  title        = {Dietary fat intake and risk of epithelial ovarian cancer in the European Prospective Investigation into Cancer and Nutrition.},
  url          = {http://dx.doi.org/10.1016/j.canep.2014.07.011},
  volume       = {38},
  year         = {2014},
}