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The impact of inflammatory lipid mediators on colon cancer-initiating cells.

Bellamkonda, Kishan LU ; Sime, Wondossen LU and Sjölander, Anita LU (2015) In Molecular Carcinogenesis 54(11). p.1315-1327
Abstract
The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like... (More)
The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Carcinogenesis
volume
54
issue
11
pages
1315 - 1327
publisher
John Wiley & Sons
external identifiers
  • pmid:25154976
  • wos:000363220700008
  • scopus:84945198930
ISSN
1098-2744
DOI
10.1002/mc.22207
language
English
LU publication?
yes
id
b31fb6e0-1f0b-41fb-bd43-02fdb9012cd3 (old id 4614004)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25154976?dopt=Abstract
date added to LUP
2014-09-09 17:19:05
date last changed
2017-11-05 03:00:12
@article{b31fb6e0-1f0b-41fb-bd43-02fdb9012cd3,
  abstract     = {The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc.},
  author       = {Bellamkonda, Kishan and Sime, Wondossen and Sjölander, Anita},
  issn         = {1098-2744},
  language     = {eng},
  number       = {11},
  pages        = {1315--1327},
  publisher    = {John Wiley & Sons},
  series       = {Molecular Carcinogenesis},
  title        = {The impact of inflammatory lipid mediators on colon cancer-initiating cells.},
  url          = {http://dx.doi.org/10.1002/mc.22207},
  volume       = {54},
  year         = {2015},
}