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Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders.

Sundquist, Jan LU ; Sundquist, Kristina LU and Ji, Jianguang LU (2014) In eLife 3(Aug 19).
Abstract
Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the... (More)
Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36-1.58) and 2.70 (95% CI 2.59-2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed.DOI: http://dx.doi.org/10.7554/eLife.02917.001. (Less)
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organization
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Contribution to journal
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published
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in
eLife
volume
3
issue
Aug 19
publisher
eLife Sciences Publications LTD.
external identifiers
  • pmid:25139954
  • wos:000341253500002
  • scopus:84929518833
ISSN
2050-084X
DOI
10.7554/eLife.02917
language
English
LU publication?
yes
id
bcd5cd88-ff33-422e-ae38-c9aaacdc69fb (old id 4614273)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25139954?dopt=Abstract
date added to LUP
2014-09-07 21:53:05
date last changed
2017-08-13 04:05:55
@article{bcd5cd88-ff33-422e-ae38-c9aaacdc69fb,
  abstract     = {Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36-1.58) and 2.70 (95% CI 2.59-2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed.DOI: http://dx.doi.org/10.7554/eLife.02917.001.},
  articleno    = {e02917},
  author       = {Sundquist, Jan and Sundquist, Kristina and Ji, Jianguang},
  issn         = {2050-084X},
  language     = {eng},
  number       = {Aug 19},
  publisher    = {eLife Sciences Publications LTD.},
  series       = {eLife},
  title        = {Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders.},
  url          = {http://dx.doi.org/10.7554/eLife.02917},
  volume       = {3},
  year         = {2014},
}