Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders.
Sundquist, Jan LU ; Sundquist, Kristina LU and Ji, Jianguang LU
(2014)
In eLife
3(Aug 19).
- Abstract
- Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the... (More)
- Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36-1.58) and 2.70 (95% CI 2.59-2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed.DOI: http://dx.doi.org/10.7554/eLife.02917.001. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4614273
- author
- Sundquist, Jan
LU
; Sundquist, Kristina
LU
and Ji, Jianguang
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- eLife
- volume
- 3
- issue
- Aug 19
- article number
- e02917
- publisher
- eLife Sciences Publications
- external identifiers
-
- pmid:25139954
- wos:000341253500002
- scopus:84929518833
- ISSN
- 2050-084X
- DOI
- 10.7554/eLife.02917
- language
- English
- LU publication?
- yes
- id
- bcd5cd88-ff33-422e-ae38-c9aaacdc69fb (old id 4614273)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25139954?dopt=Abstract
- date added to LUP
- 2016-04-01 14:28:21
- date last changed
- 2022-01-28 00:46:26
@article{bcd5cd88-ff33-422e-ae38-c9aaacdc69fb,
abstract = {{Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in germ cells (sperms or eggs), we examine here whether the risks of autism and ADHD are increased among individuals with a family history of alcohol use disorders (AUDs). The standardized incidence ratios (SIRs) of autism and ADHD among individuals with a biological parental history of AUDs were 1.39 (95% CI 1.34-1.44) and 2.19 (95% CI 2.15-2.23), respectively, compared to individuals without an affected parent. Among offspring whose parents were diagnosed with AUDs before their birth, the corresponding risks were 1.46 (95% CI 1.36-1.58) and 2.70 (95% CI 2.59-2.81), respectively. Our study calls for extra surveillance for children with a family history of AUDs, and further studies examining the underlying mechanisms are needed.DOI: http://dx.doi.org/10.7554/eLife.02917.001.}},
author = {{Sundquist, Jan and Sundquist, Kristina and Ji, Jianguang}},
issn = {{2050-084X}},
language = {{eng}},
number = {{Aug 19}},
publisher = {{eLife Sciences Publications}},
series = {{eLife}},
title = {{Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders.}},
url = {{https://lup.lub.lu.se/search/files/3994437/8147427}},
doi = {{10.7554/eLife.02917}},
volume = {{3}},
year = {{2014}},
}