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Intratumorally implanted mesenchymal stromal cells potentiate peripheral immunotherapy against malignant rat gliomas.

Ströjby, Salina; Eberstål, Sofia LU ; Svensson, Andreas LU ; Fritzell, Sara LU ; Bexell, Daniel LU ; Siesjö, Peter LU ; Darabi, Anna LU and Bengzon, Johan LU (2014) In Journal of Neuroimmunology 274(1-2). p.240-243
Abstract
Bone marrow-derived mesenchymal stromal cells (MSCs) target glioma extensions and micro-satellites efficiently when implanted intratumorally. Here, we report that intratumoral implantation of MSCs and peripheral immunotherapy with interferon-gamma (IFNγ) producing tumor cells improve the survival of glioma-bearing rats (54% cure rate) compared to MSC alone (0% cure rate) or immunotherapy alone (21% cure rate) by enforcing an intratumoral CD8(+) T cell response. Further analysis revealed that the MSCs up-regulate MHC classes I and II in response to IFNγ treatment in vitro and secrete low amounts of immunosuppressive molecules prostaglandin E2 and interleukin-10.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroimmunology
volume
274
issue
1-2
pages
240 - 243
publisher
Elsevier
external identifiers
  • pmid:25086876
  • wos:000342871600033
  • scopus:84906937667
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2014.07.014
language
English
LU publication?
yes
id
e3e89d2d-6837-44b2-8299-75221547b09a (old id 4615653)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25086876?dopt=Abstract
date added to LUP
2014-09-03 20:53:16
date last changed
2017-10-01 03:11:01
@article{e3e89d2d-6837-44b2-8299-75221547b09a,
  abstract     = {Bone marrow-derived mesenchymal stromal cells (MSCs) target glioma extensions and micro-satellites efficiently when implanted intratumorally. Here, we report that intratumoral implantation of MSCs and peripheral immunotherapy with interferon-gamma (IFNγ) producing tumor cells improve the survival of glioma-bearing rats (54% cure rate) compared to MSC alone (0% cure rate) or immunotherapy alone (21% cure rate) by enforcing an intratumoral CD8(+) T cell response. Further analysis revealed that the MSCs up-regulate MHC classes I and II in response to IFNγ treatment in vitro and secrete low amounts of immunosuppressive molecules prostaglandin E2 and interleukin-10.},
  author       = {Ströjby, Salina and Eberstål, Sofia and Svensson, Andreas and Fritzell, Sara and Bexell, Daniel and Siesjö, Peter and Darabi, Anna and Bengzon, Johan},
  issn         = {1872-8421},
  language     = {eng},
  number       = {1-2},
  pages        = {240--243},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {Intratumorally implanted mesenchymal stromal cells potentiate peripheral immunotherapy against malignant rat gliomas.},
  url          = {http://dx.doi.org/10.1016/j.jneuroim.2014.07.014},
  volume       = {274},
  year         = {2014},
}