Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

Ernfors, Patrik ; Bengzon, Johan LU ; Kokaia, Zaal LU orcid ; Persson, Håkan LU and Lindvall, Olle LU (1991) In Neuron 7(1). p.165-176
Abstract

Kindling, induced by repeated subconvulsive electrical or chemical stimulations leads to progressive and permanent amplification of seizure activity, culminating in generalized seizures. We report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase of mRNA for NGF and BDNF in the dentate gyrus, the parietal cortex, and the piriform cortex. BDNF mRNA increased also in the pyramidal layer of hippocampus and in the amygdaloid complex. No change was seen in the level of HDNF/NT-3 mRNA. The increased expression of NGF and BDNF mRNAs was not influenced by pretreatment with the NMDA receptor antagonist MK801, but was partially blocked by the quisqualate, AMPA receptor antagonist... (More)

Kindling, induced by repeated subconvulsive electrical or chemical stimulations leads to progressive and permanent amplification of seizure activity, culminating in generalized seizures. We report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase of mRNA for NGF and BDNF in the dentate gyrus, the parietal cortex, and the piriform cortex. BDNF mRNA increased also in the pyramidal layer of hippocampus and in the amygdaloid complex. No change was seen in the level of HDNF/NT-3 mRNA. The increased expression of NGF and BDNF mRNAs was not influenced by pretreatment with the NMDA receptor antagonist MK801, but was partially blocked by the quisqualate, AMPA receptor antagonist NBQX. The presumed subsequent increase of the trophic factors themselves may be important for kindling-associated plasticity in specific neuronal systems in the hippocampus, which could promote hyperexcitability and contribute to the development of epileptic syndromes.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Neuron
volume
7
issue
1
pages
12 pages
publisher
Cell Press
external identifiers
  • pmid:1829904
  • scopus:0025766899
ISSN
0896-6273
DOI
10.1016/0896-6273(91)90084-D
language
English
LU publication?
no
id
462acb2c-4145-4e15-9727-080bc0e4541a
date added to LUP
2019-09-03 17:09:48
date last changed
2024-01-01 18:58:33
@article{462acb2c-4145-4e15-9727-080bc0e4541a,
  abstract     = {{<p>Kindling, induced by repeated subconvulsive electrical or chemical stimulations leads to progressive and permanent amplification of seizure activity, culminating in generalized seizures. We report that kindling induced by electrical stimulation in the ventral hippocampus leads to a marked and transient increase of mRNA for NGF and BDNF in the dentate gyrus, the parietal cortex, and the piriform cortex. BDNF mRNA increased also in the pyramidal layer of hippocampus and in the amygdaloid complex. No change was seen in the level of HDNF/NT-3 mRNA. The increased expression of NGF and BDNF mRNAs was not influenced by pretreatment with the NMDA receptor antagonist MK801, but was partially blocked by the quisqualate, AMPA receptor antagonist NBQX. The presumed subsequent increase of the trophic factors themselves may be important for kindling-associated plasticity in specific neuronal systems in the hippocampus, which could promote hyperexcitability and contribute to the development of epileptic syndromes.</p>}},
  author       = {{Ernfors, Patrik and Bengzon, Johan and Kokaia, Zaal and Persson, Håkan and Lindvall, Olle}},
  issn         = {{0896-6273}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{165--176}},
  publisher    = {{Cell Press}},
  series       = {{Neuron}},
  title        = {{Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis}},
  url          = {{http://dx.doi.org/10.1016/0896-6273(91)90084-D}},
  doi          = {{10.1016/0896-6273(91)90084-D}},
  volume       = {{7}},
  year         = {{1991}},
}