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Improvement in survival of diffuse large B-cell lymphoma in relation to age, gender, International Prognostic Index and extranodal presentation: a population based Swedish Lymphoma Registry study

Szekely, Elisabeth; Hagberg, Oskar LU ; Arnljots, Kristina LU and Jerkeman, Mats LU (2014) In Leukemia & Lymphoma 55(8). p.1838-1843
Abstract
Our aim was to describe a large population-based cohort of diffuse large B-cell lymphoma (DLBCL) during the last decade, evaluating possible improvement in survival and to identify subgroups in need of novel treatment strategies. The study population encompassed all patients diagnosed with DLBCL in Sweden from 2000 through 2010. Altogether 5349 patients were identified. There was no increase in incidence for females, but for males there was an estimated yearly increase in incidence by 0.019 per 10 000. When adjusted for age and gender, the improvement in overall survival for the whole group was estimated at 4.5% per year, most prominent in the age group 60-78 years, and in patients with good performance status. In this large dataset, we... (More)
Our aim was to describe a large population-based cohort of diffuse large B-cell lymphoma (DLBCL) during the last decade, evaluating possible improvement in survival and to identify subgroups in need of novel treatment strategies. The study population encompassed all patients diagnosed with DLBCL in Sweden from 2000 through 2010. Altogether 5349 patients were identified. There was no increase in incidence for females, but for males there was an estimated yearly increase in incidence by 0.019 per 10 000. When adjusted for age and gender, the improvement in overall survival for the whole group was estimated at 4.5% per year, most prominent in the age group 60-78 years, and in patients with good performance status. In this large dataset, we were able to detect a clear improvement in overall survival in DLBCL, although restricted to specific prognostic subgroups, and to identify specific disease presentations that significantly affect overall survival. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diffuse large B-cell lymphoma, prognostic factors, chemotherapy, incidence
in
Leukemia & Lymphoma
volume
55
issue
8
pages
1838 - 1843
publisher
Taylor & Francis
external identifiers
  • wos:000340224100024
  • scopus:84904908923
ISSN
1042-8194
DOI
10.3109/10428194.2013.853297
language
English
LU publication?
yes
id
cced87da-a36a-429d-9f17-38e678ee5d42 (old id 4652908)
date added to LUP
2014-10-01 07:26:36
date last changed
2017-07-02 04:03:56
@article{cced87da-a36a-429d-9f17-38e678ee5d42,
  abstract     = {Our aim was to describe a large population-based cohort of diffuse large B-cell lymphoma (DLBCL) during the last decade, evaluating possible improvement in survival and to identify subgroups in need of novel treatment strategies. The study population encompassed all patients diagnosed with DLBCL in Sweden from 2000 through 2010. Altogether 5349 patients were identified. There was no increase in incidence for females, but for males there was an estimated yearly increase in incidence by 0.019 per 10 000. When adjusted for age and gender, the improvement in overall survival for the whole group was estimated at 4.5% per year, most prominent in the age group 60-78 years, and in patients with good performance status. In this large dataset, we were able to detect a clear improvement in overall survival in DLBCL, although restricted to specific prognostic subgroups, and to identify specific disease presentations that significantly affect overall survival.},
  author       = {Szekely, Elisabeth and Hagberg, Oskar and Arnljots, Kristina and Jerkeman, Mats},
  issn         = {1042-8194},
  keyword      = {Diffuse large B-cell lymphoma,prognostic factors,chemotherapy,incidence},
  language     = {eng},
  number       = {8},
  pages        = {1838--1843},
  publisher    = {Taylor & Francis},
  series       = {Leukemia & Lymphoma},
  title        = {Improvement in survival of diffuse large B-cell lymphoma in relation to age, gender, International Prognostic Index and extranodal presentation: a population based Swedish Lymphoma Registry study},
  url          = {http://dx.doi.org/10.3109/10428194.2013.853297},
  volume       = {55},
  year         = {2014},
}