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Potential of multi-photon upconversion emissions for fluorescence diffuse optical imaging

Liu, Haichun LU ; Xu, Can LU and Andersson-Engels, Stefan LU (2014) In Optics Express 22(15). p.17782-17790
Abstract
The spatial resolution of fluorescence molecular imaging is a critical issue for the success of the technique in biomedical applications. One important method for increasing the imaging resolution is to utilize multi-photon emissions. In this study, we thoroughly investigate the potential of the multi-photon upconversion emissions from rare-earth-doped upconverting nanoparticles for the improvement in spatial resolution of diffuse optical imaging. It is found that the imaging resolution is increased by a factor of 1.45 through employing two-photon upconversion emission compared with using the linear emission, and can be further elevated by a factor of 1.23 by using three-photon upconversion emission. In addition, we demonstrate that the... (More)
The spatial resolution of fluorescence molecular imaging is a critical issue for the success of the technique in biomedical applications. One important method for increasing the imaging resolution is to utilize multi-photon emissions. In this study, we thoroughly investigate the potential of the multi-photon upconversion emissions from rare-earth-doped upconverting nanoparticles for the improvement in spatial resolution of diffuse optical imaging. It is found that the imaging resolution is increased by a factor of 1.45 through employing two-photon upconversion emission compared with using the linear emission, and can be further elevated by a factor of 1.23 by using three-photon upconversion emission. In addition, we demonstrate that the pulsed excitation approach holds the promise of overcoming the low quantum yield associated with the high-order upconversion emissions. (C) 2014 Optical Society of America (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
22
issue
15
pages
17782 - 17790
publisher
OSA
external identifiers
  • wos:000340685600020
  • scopus:84905374484
ISSN
1094-4087
DOI
10.1364/OE.22.017782
language
English
LU publication?
yes
id
244478a9-7464-4723-84b2-784538048e17 (old id 4655936)
date added to LUP
2014-09-24 11:13:09
date last changed
2017-01-01 06:35:21
@article{244478a9-7464-4723-84b2-784538048e17,
  abstract     = {The spatial resolution of fluorescence molecular imaging is a critical issue for the success of the technique in biomedical applications. One important method for increasing the imaging resolution is to utilize multi-photon emissions. In this study, we thoroughly investigate the potential of the multi-photon upconversion emissions from rare-earth-doped upconverting nanoparticles for the improvement in spatial resolution of diffuse optical imaging. It is found that the imaging resolution is increased by a factor of 1.45 through employing two-photon upconversion emission compared with using the linear emission, and can be further elevated by a factor of 1.23 by using three-photon upconversion emission. In addition, we demonstrate that the pulsed excitation approach holds the promise of overcoming the low quantum yield associated with the high-order upconversion emissions. (C) 2014 Optical Society of America},
  author       = {Liu, Haichun and Xu, Can and Andersson-Engels, Stefan},
  issn         = {1094-4087},
  language     = {eng},
  number       = {15},
  pages        = {17782--17790},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Potential of multi-photon upconversion emissions for fluorescence diffuse optical imaging},
  url          = {http://dx.doi.org/10.1364/OE.22.017782},
  volume       = {22},
  year         = {2014},
}