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25-Hydroxyvitamin D and Cardiovascular Disease in Patients With Systemic Lupus Erythematosus: Data From a Large International Inception Cohort

Lertratanakul, Apinya; Wu, Peggy; Dyer, Alan; Urowitz, Murray; Gladman, Dafna; Fortin, Paul; Bae, Sang-Cheol; Gordon, Caroline; Clarke, Ann and Bernatsky, Sasha, et al. (2014) In Arthritis Care and Research1988-01-01+01:002000-01-01+01:00 66(8). p.1167-1176
Abstract
Objective. An association between 25-hydroxyvitamin D (25[ OH] D; vitamin D) deficiency and increased cardiovascular (CV) risk factors and CV disease (CVD) has been shown in general population studies. Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause of morbidity and mortality in SLE. The objectives of this study were to estimate the associations of 25(OH) D levels with CV risk factors and to determine whether low baseline 25(OH) D levels predict future CV events in patients participating in an international inception cohort. Methods. Data were collected on 890 participants, including demographics, SLE activity and damage assessments, CV risk factors and events, medications, laboratory... (More)
Objective. An association between 25-hydroxyvitamin D (25[ OH] D; vitamin D) deficiency and increased cardiovascular (CV) risk factors and CV disease (CVD) has been shown in general population studies. Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause of morbidity and mortality in SLE. The objectives of this study were to estimate the associations of 25(OH) D levels with CV risk factors and to determine whether low baseline 25(OH) D levels predict future CV events in patients participating in an international inception cohort. Methods. Data were collected on 890 participants, including demographics, SLE activity and damage assessments, CV risk factors and events, medications, laboratory assessments of 25(OH) D levels, and inflammatory markers. Multiple logistic and Cox regressions were used to estimate the associations of baseline 25(OH) D levels with baseline CV risk factors and CVD events. The models were adjusted for age, sex, race, season, and country, with and without body mass index. Results. Patients in the higher quartiles of 25(OH) D were less likely to have hypertension and hyperlipidemia and were more likely to have lower C-reactive protein levels and lower Systemic Lupus Erythematosus Disease Activity Index 2000 scores at baseline when compared with the first quartile. Vitamin D levels were not independently associated with CVD event incidence; however, hazard ratios for CVD event incidence decreased with successively higher quartiles. Conclusion. Lower baseline 25(OH) D levels are associated with higher risk for CV risk factors and more active SLE at baseline. There may be a trend toward a lower likelihood of CVD events in those with higher baseline 25(OH) D levels. (Less)
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published
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Arthritis Care and Research1988-01-01+01:002000-01-01+01:00
volume
66
issue
8
pages
1167 - 1176
publisher
John Wiley & Sons
external identifiers
  • wos:000340356600005
  • scopus:84905046025
ISSN
2151-4658
DOI
10.1002/acr.22291
language
English
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yes
id
9628c616-bdcf-4e83-89a1-f8a2756b67fb (old id 4659241)
date added to LUP
2014-10-01 07:25:29
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2017-11-05 03:12:08
@article{9628c616-bdcf-4e83-89a1-f8a2756b67fb,
  abstract     = {Objective. An association between 25-hydroxyvitamin D (25[ OH] D; vitamin D) deficiency and increased cardiovascular (CV) risk factors and CV disease (CVD) has been shown in general population studies. Vitamin D deficiency has been noted in systemic lupus erythematosus (SLE), and CVD is a major cause of morbidity and mortality in SLE. The objectives of this study were to estimate the associations of 25(OH) D levels with CV risk factors and to determine whether low baseline 25(OH) D levels predict future CV events in patients participating in an international inception cohort. Methods. Data were collected on 890 participants, including demographics, SLE activity and damage assessments, CV risk factors and events, medications, laboratory assessments of 25(OH) D levels, and inflammatory markers. Multiple logistic and Cox regressions were used to estimate the associations of baseline 25(OH) D levels with baseline CV risk factors and CVD events. The models were adjusted for age, sex, race, season, and country, with and without body mass index. Results. Patients in the higher quartiles of 25(OH) D were less likely to have hypertension and hyperlipidemia and were more likely to have lower C-reactive protein levels and lower Systemic Lupus Erythematosus Disease Activity Index 2000 scores at baseline when compared with the first quartile. Vitamin D levels were not independently associated with CVD event incidence; however, hazard ratios for CVD event incidence decreased with successively higher quartiles. Conclusion. Lower baseline 25(OH) D levels are associated with higher risk for CV risk factors and more active SLE at baseline. There may be a trend toward a lower likelihood of CVD events in those with higher baseline 25(OH) D levels.},
  author       = {Lertratanakul, Apinya and Wu, Peggy and Dyer, Alan and Urowitz, Murray and Gladman, Dafna and Fortin, Paul and Bae, Sang-Cheol and Gordon, Caroline and Clarke, Ann and Bernatsky, Sasha and Hanly, John G. and Isenberg, David and Rahman, Anisur and Merrill, Joan and Wallace, Daniel J. and Ginzler, Ellen and Khamashta, Munther and Bruce, Ian and Nived, Ola and Sturfelt, Gunnar and Steinsson, Kristjan and Manzi, Susan and Dooley, Mary Anne and Kalunian, Kenneth and Petri, Michelle and Aranow, Cynthia and Font, Josep and van Vollenhoven, Ronald and Stoll, Thomas and Ramsey-Goldman, Rosalind},
  issn         = {2151-4658},
  language     = {eng},
  number       = {8},
  pages        = {1167--1176},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis Care and Research1988-01-01+01:002000-01-01+01:00},
  title        = {25-Hydroxyvitamin D and Cardiovascular Disease in Patients With Systemic Lupus Erythematosus: Data From a Large International Inception Cohort},
  url          = {http://dx.doi.org/10.1002/acr.22291},
  volume       = {66},
  year         = {2014},
}