Familial Ovarian Cancer Clusters with Other Cancers
(2018) In Scientific Reports 8(1).- Abstract
Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in... (More)
Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in families with ovarian cancer patients, and dose-responses were shown for risks of liver (P-trend = 0.0083) and breast cancers (P-trend <0.0001) and cancer of unknown primary (P-trend = 0.0157). Some cancers were only associated with histology-specific ovarian cancers, e.g. endometrial cancer was only associated with endometrioid type but with highest significance. Novel associations with virus-linked cancers of the nose and male and female genitals were found. The results suggest that ovarian cancer shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification.
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- author
- Zheng, Guoqiao LU ; Yu, Hongyao LU ; Kanerva, Anna ; Försti, Asta LU ; Sundquist, Kristina LU and Hemminki, Kari LU
- organization
- publishing date
- 2018-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 8
- issue
- 1
- article number
- 11561
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85050958332
- pmid:30069056
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-018-29888-4
- language
- English
- LU publication?
- yes
- id
- 46622f4b-7d40-4c2b-8f34-3b41491bd2db
- date added to LUP
- 2018-08-14 13:43:39
- date last changed
- 2024-09-02 23:50:46
@article{46622f4b-7d40-4c2b-8f34-3b41491bd2db, abstract = {{<p>Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in families with ovarian cancer patients, and dose-responses were shown for risks of liver (P-trend = 0.0083) and breast cancers (P-trend <0.0001) and cancer of unknown primary (P-trend = 0.0157). Some cancers were only associated with histology-specific ovarian cancers, e.g. endometrial cancer was only associated with endometrioid type but with highest significance. Novel associations with virus-linked cancers of the nose and male and female genitals were found. The results suggest that ovarian cancer shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification.</p>}}, author = {{Zheng, Guoqiao and Yu, Hongyao and Kanerva, Anna and Försti, Asta and Sundquist, Kristina and Hemminki, Kari}}, issn = {{2045-2322}}, language = {{eng}}, month = {{08}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Familial Ovarian Cancer Clusters with Other Cancers}}, url = {{http://dx.doi.org/10.1038/s41598-018-29888-4}}, doi = {{10.1038/s41598-018-29888-4}}, volume = {{8}}, year = {{2018}}, }