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Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease

Chung, Sun Ju; Biernacka, Joanna M.; Armasu, Sebastian M.; Anderson, Kari; Frigerio, Roberta; Aasly, Jan O.; Annesi, Grazia; Bentivoglio, Anna Rita; Brighina, Laura and Chartier-Harlin, Marie-Christine, et al. (2014) In Movement Disorders 29(8). p.1053-1057
Abstract
Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence... (More)
Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society (Less)
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@article{e956cbb6-27b2-4b6b-b665-4b9a84b62883,
  abstract     = {Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society},
  author       = {Chung, Sun Ju and Biernacka, Joanna M. and Armasu, Sebastian M. and Anderson, Kari and Frigerio, Roberta and Aasly, Jan O. and Annesi, Grazia and Bentivoglio, Anna Rita and Brighina, Laura and Chartier-Harlin, Marie-Christine and Goldwurm, Stefano and Hadjigeorgiou, Georgios and Jasinska-Myga, Barbara and Jeon, Beom Seok and Kim, Yun Joong and Krueger, Rejko and Lesage, Suzanne and Markopoulou, Katerina and Mellick, George and Morrison, Karen E. and Puschmann, Andreas and Tan, Eng-King and Crosiers, David and Theuns, Jessie and Van Broeckhoven, Christine and Wirdefeldt, Karin and Wszolek, Zbigniew K. and Elbaz, Alexis and Maraganore, Demetrius M.},
  issn         = {0885-3185},
  keyword      = {Parkinson's disease,alpha-synuclein,gene,survival,association},
  language     = {eng},
  number       = {8},
  pages        = {1053--1057},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease},
  url          = {http://dx.doi.org/10.1002/mds.25841},
  volume       = {29},
  year         = {2014},
}