Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Evaluation of intra- and extracellular activity of trimethoprim-sulfamethoxazole against susceptible and multidrug-resistant Mycobacterium tuberculosis.

Davies Forsman, L ; Schön, T ; Simonsson, U S H ; Bruchfeld, J ; Larsson, M ; Juréen, P ; Sturegård, Erik LU ; Giske, C G and Angeby, K (2014) In Antimicrobial Agents and Chemotherapy 58(12). p.7557-7559
Abstract
We investigated the activity of trimethoprim-sulfamethoxazole (SXT) against Mycobacterium tuberculosis. The MIC distribution of SXT was 0.125/2.4-2/38 mg/L for the 100 isolates tested, including multi- and extensively drug-resistant isolates (MDR/XDR-TB), whereas the intracellular MIC90 of sulfamethoxazole (SMX) for H37Rv was 76 mg/L. In an exploratory analysis using fAUC0-24h/MIC ≥25 as a potential target, the cumulative fraction response was ≥90% at doses ≥2400 mg of SMX. SXT is a potential treatment option for MDR/XDR-TB.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Antimicrobial Agents and Chemotherapy
volume
58
issue
12
pages
7557 - 7559
publisher
American Society for Microbiology
external identifiers
  • pmid:25246405
  • wos:000345221000065
  • scopus:84912120697
  • pmid:25246405
ISSN
1098-6596
DOI
10.1128/AAC.02995-14
language
English
LU publication?
yes
id
0517dd7a-b403-4386-b2ec-86c1d1b575cb (old id 4691052)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25246405?dopt=Abstract
date added to LUP
2016-04-01 10:26:14
date last changed
2022-04-27 22:03:00
@article{0517dd7a-b403-4386-b2ec-86c1d1b575cb,
  abstract     = {{We investigated the activity of trimethoprim-sulfamethoxazole (SXT) against Mycobacterium tuberculosis. The MIC distribution of SXT was 0.125/2.4-2/38 mg/L for the 100 isolates tested, including multi- and extensively drug-resistant isolates (MDR/XDR-TB), whereas the intracellular MIC90 of sulfamethoxazole (SMX) for H37Rv was 76 mg/L. In an exploratory analysis using fAUC0-24h/MIC ≥25 as a potential target, the cumulative fraction response was ≥90% at doses ≥2400 mg of SMX. SXT is a potential treatment option for MDR/XDR-TB.}},
  author       = {{Davies Forsman, L and Schön, T and Simonsson, U S H and Bruchfeld, J and Larsson, M and Juréen, P and Sturegård, Erik and Giske, C G and Angeby, K}},
  issn         = {{1098-6596}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{7557--7559}},
  publisher    = {{American Society for Microbiology}},
  series       = {{Antimicrobial Agents and Chemotherapy}},
  title        = {{Evaluation of intra- and extracellular activity of trimethoprim-sulfamethoxazole against susceptible and multidrug-resistant Mycobacterium tuberculosis.}},
  url          = {{http://dx.doi.org/10.1128/AAC.02995-14}},
  doi          = {{10.1128/AAC.02995-14}},
  volume       = {{58}},
  year         = {{2014}},
}