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Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.

Vikingsson, Svante; Andersson, David LU ; Almer, Sven; Peterson, Curt and Hindorf, Ulf LU (2014) In Journal of Crohn's & Colitis 8(12). p.1702-1709
Abstract
The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Crohn's & Colitis
volume
8
issue
12
pages
1702 - 1709
publisher
Elsevier
external identifiers
  • pmid:25239576
  • wos:000347019600016
  • scopus:84918500592
ISSN
1873-9946
DOI
10.1016/j.crohns.2014.08.009
language
English
LU publication?
yes
id
b2d3dd05-8854-44ac-841d-e9b01debac36 (old id 4691187)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25239576?dopt=Abstract
date added to LUP
2014-10-07 22:22:21
date last changed
2017-11-05 03:18:43
@article{b2d3dd05-8854-44ac-841d-e9b01debac36,
  abstract     = {The thiopurines are widely used in the treatment of inflammatory bowel disease, but are limited by poor dose-effect relationship. The objective was to assess the ability of a novel assay, determining the mono-, di-, and triphosphates, of thioguanine as well as methylthioinosine as individual metabolites in erythrocytes, to predict clinical outcome compared to a routine assay, determining metabolites as sums.},
  author       = {Vikingsson, Svante and Andersson, David and Almer, Sven and Peterson, Curt and Hindorf, Ulf},
  issn         = {1873-9946},
  language     = {eng},
  number       = {12},
  pages        = {1702--1709},
  publisher    = {Elsevier},
  series       = {Journal of Crohn's & Colitis},
  title        = {Novel assay to improve therapeutic drug monitoring of thiopurines in inflammatory bowel disease.},
  url          = {http://dx.doi.org/10.1016/j.crohns.2014.08.009},
  volume       = {8},
  year         = {2014},
}