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Greater loss of von Economo neurons than loss of layer II and III neurons in behavioral variant frontotemporal dementia.

Santillo, Alexander LU and Englund, Elisabet LU (2014) In American Journal of Neurodegenerative Disease 3(2). p.64-71
Abstract
Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to examine loss the loss of VENs in comparison with that of non-VEN-neurons of superficial cortical layers. VENs and non-VEN-neurons of cortical layer V and layers II+III were quantified in the anterior cingulate cortex in 16 cases of bvFTD, 12 non-demented controls and 10 cases of Alzheimer's disease (AD). In bvFTD VENs were more depleted than... (More)
Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to examine loss the loss of VENs in comparison with that of non-VEN-neurons of superficial cortical layers. VENs and non-VEN-neurons of cortical layer V and layers II+III were quantified in the anterior cingulate cortex in 16 cases of bvFTD, 12 non-demented controls and 10 cases of Alzheimer's disease (AD). In bvFTD VENs were more depleted than non-VEN-neurons of layers V and II+III. Also, non-VEN-neurons of layer II+III showed a greater density reduction than those of layer V in bvFTD. VEN density was also reduced in AD, albeit to a lesser extent than in bvFTD, and the differences between bvFTD and AD were only significant when relating VEN loss to that of layer V neurons. Our study strengthens the view of VENs as a particularly sensitive neuronal type of bvFTD, and appears to be on a continuum with the loss of other neurons both in bvFTD and between conditions. (Less)
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author
organization
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Contribution to journal
publication status
published
subject
in
American Journal of Neurodegenerative Disease
volume
3
issue
2
pages
64 - 71
publisher
e-Century Publishing
external identifiers
  • pmid:25232511
  • scopus:84980053693
ISSN
2165-591X
language
English
LU publication?
yes
id
0aff9ce8-b5d4-4034-9b97-b30078924662 (old id 4691306)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25232511?dopt=Abstract
date added to LUP
2014-10-07 20:37:12
date last changed
2017-09-17 06:54:46
@article{0aff9ce8-b5d4-4034-9b97-b30078924662,
  abstract     = {Previous studies have shown a selective reduction of von Economo neurons (VENs) in behavioral variant frontotemporal dementia (bvFTD). However, the alleged selectivity rests on the comparison between VENs and other neurons in cortical layer V, while it has been established that neurons in the superficial cortical layers (I-III) are particularly affected in bvFTD. The purpose of this study was to examine loss the loss of VENs in comparison with that of non-VEN-neurons of superficial cortical layers. VENs and non-VEN-neurons of cortical layer V and layers II+III were quantified in the anterior cingulate cortex in 16 cases of bvFTD, 12 non-demented controls and 10 cases of Alzheimer's disease (AD). In bvFTD VENs were more depleted than non-VEN-neurons of layers V and II+III. Also, non-VEN-neurons of layer II+III showed a greater density reduction than those of layer V in bvFTD. VEN density was also reduced in AD, albeit to a lesser extent than in bvFTD, and the differences between bvFTD and AD were only significant when relating VEN loss to that of layer V neurons. Our study strengthens the view of VENs as a particularly sensitive neuronal type of bvFTD, and appears to be on a continuum with the loss of other neurons both in bvFTD and between conditions.},
  author       = {Santillo, Alexander and Englund, Elisabet},
  issn         = {2165-591X},
  language     = {eng},
  number       = {2},
  pages        = {64--71},
  publisher    = {e-Century Publishing},
  series       = {American Journal of Neurodegenerative Disease},
  title        = {Greater loss of von Economo neurons than loss of layer II and III neurons in behavioral variant frontotemporal dementia.},
  volume       = {3},
  year         = {2014},
}