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Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.

Lindgren, Gustaf LU ; Ekblad, Lars LU ; Vallon-Christersson, Johan LU ; Kjellén, Elisabeth LU ; Gebre-Medhin, Maria LU and Wennerberg, Johan LU (2014) In BMC Cancer 14.
Abstract
Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
14
publisher
BioMed Central
external identifiers
  • pmid:25182342
  • wos:000341737500001
  • scopus:84907387754
ISSN
1471-2407
DOI
10.1186/1471-2407-14-648
language
English
LU publication?
yes
id
9c1e8d29-8bf2-475e-a26a-5b43303c40ca (old id 4692467)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25182342?dopt=Abstract
date added to LUP
2014-10-01 14:15:52
date last changed
2017-08-24 14:32:00
@article{9c1e8d29-8bf2-475e-a26a-5b43303c40ca,
  abstract     = {Several studies on the use of erythropoietin (Epo) to treat anaemia in patients undergoing cancer treatment have shown adverse effects on tumour control and survival. Experimental studies indicate that this could be linked to an interaction with wound healing processes and not an effect on tumour cells per se. We have previously shown that erythropoietin in combination with surgical trauma stimulates tumour growth. In the present study, we investigated the effect of surgery and Epo on gene expression.},
  articleno    = {648},
  author       = {Lindgren, Gustaf and Ekblad, Lars and Vallon-Christersson, Johan and Kjellén, Elisabeth and Gebre-Medhin, Maria and Wennerberg, Johan},
  issn         = {1471-2407},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Cancer},
  title        = {Erythropoietin suppresses the activation of pro-apoptotic genes in head and neck squamous cell carcinoma xenografts exposed to surgical trauma.},
  url          = {http://dx.doi.org/10.1186/1471-2407-14-648},
  volume       = {14},
  year         = {2014},
}