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Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study

Lundström, Sebastian; Reichenberg, Abraham; Melke, Jonas; Råstam, Maria LU ; Kerekes, Nora; Lichtenstein, Paul; Gillberg, Christopher and Anckarsäter, Henrik LU (2015) In Journal of Child Psychology and Psychiatry and Allied Disciplines 56(6). p.702-710
Abstract
Background: Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods: Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known... (More)
Background: Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods: Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results: Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did

not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions: Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders

may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autism spectrum disorders, comorbidity, genetics, twins
in
Journal of Child Psychology and Psychiatry and Allied Disciplines
volume
56
issue
6
pages
702 - 710
publisher
Wiley-Blackwell
external identifiers
  • wos:000354464300011
  • scopus:84929148230
ISSN
1469-7610
DOI
10.1111/jcpp.12329
language
English
LU publication?
yes
id
e8bcc286-4f3b-4544-9846-c961572e31cd (old id 4697451)
date added to LUP
2015-02-22 10:01:43
date last changed
2017-11-12 03:16:11
@article{e8bcc286-4f3b-4544-9846-c961572e31cd,
  abstract     = {Background: Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods: Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results: Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did<br/><br>
not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions: Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders<br/><br>
may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically.},
  author       = {Lundström, Sebastian and Reichenberg, Abraham and Melke, Jonas and Råstam, Maria and Kerekes, Nora and Lichtenstein, Paul and Gillberg, Christopher and Anckarsäter, Henrik},
  issn         = {1469-7610},
  keyword      = {Autism spectrum disorders,comorbidity,genetics,twins},
  language     = {eng},
  number       = {6},
  pages        = {702--710},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Child Psychology and Psychiatry and Allied Disciplines},
  title        = {Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study},
  url          = {http://dx.doi.org/10.1111/jcpp.12329},
  volume       = {56},
  year         = {2015},
}