Emergency subtotal colectomy rates in relation to anti-TNF therapy in inflammatory bowel disease patients : comparison of retrospective cohorts
(2023) In Scandinavian Journal of Gastroenterology 58(1). p.15-19- Abstract
Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for acute severe colitis at Skåne University Hospital, Sweden, during two six-year windows were included. The two time-windows represented pre- and introductory (2004–2009) versus post-introductory (2012–2017) anti-TNF therapy usage. The two periods were compared in terms of the proportion of patients who received anti-TNF therapy, rates of emergency... (More)
Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for acute severe colitis at Skåne University Hospital, Sweden, during two six-year windows were included. The two time-windows represented pre- and introductory (2004–2009) versus post-introductory (2012–2017) anti-TNF therapy usage. The two periods were compared in terms of the proportion of patients who received anti-TNF therapy, rates of emergency subtotal colectomy, and local IBD prevalence numbers. Results: In total 91 patients were included, 42 (2004–2009) and 49 (2012–2017) patients, respectively. The proportion of patients that received anti-TNF therapy prior to admission was increased from 29% (2004–2009) to 63% (2012–2017) (p =.001). Despite this no significant difference was found in the emergency subtotal colectomy rates between the time periods considering the population at risk (IBD patients living in Skåne county); 1.44/1000 person years versus 1.37/1000 person years (p =.83). Conclusion: Despite an increased proportion of patients with IBD that received anti-TNF therapy prior to admission, no significant decrease in emergency subtotal colectomy rates was noted. Further research is warranted, and a prospective study design would facilitate a better causal understanding.
(Less)
- author
- Sajjadi, Saman LU ; Svensson Neufert, Rebecca LU ; Ruhr, Emilia ; Tryggmo, Sebastian ; Marsal, Jan LU and Buchwald, Pamela LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- anti-TNF, biological therapy, colectomy, Inflammatory bowel disease, surgery
- in
- Scandinavian Journal of Gastroenterology
- volume
- 58
- issue
- 1
- pages
- 15 - 19
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:35917586
- scopus:85135225529
- ISSN
- 0036-5521
- DOI
- 10.1080/00365521.2022.2106151
- language
- English
- LU publication?
- yes
- id
- 46a859f4-a2bc-4cd6-a959-dfc2bdc0477f
- date added to LUP
- 2022-10-06 10:32:23
- date last changed
- 2024-09-20 05:05:08
@article{46a859f4-a2bc-4cd6-a959-dfc2bdc0477f, abstract = {{<p>Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for acute severe colitis at Skåne University Hospital, Sweden, during two six-year windows were included. The two time-windows represented pre- and introductory (2004–2009) versus post-introductory (2012–2017) anti-TNF therapy usage. The two periods were compared in terms of the proportion of patients who received anti-TNF therapy, rates of emergency subtotal colectomy, and local IBD prevalence numbers. Results: In total 91 patients were included, 42 (2004–2009) and 49 (2012–2017) patients, respectively. The proportion of patients that received anti-TNF therapy prior to admission was increased from 29% (2004–2009) to 63% (2012–2017) (p =.001). Despite this no significant difference was found in the emergency subtotal colectomy rates between the time periods considering the population at risk (IBD patients living in Skåne county); 1.44/1000 person years versus 1.37/1000 person years (p =.83). Conclusion: Despite an increased proportion of patients with IBD that received anti-TNF therapy prior to admission, no significant decrease in emergency subtotal colectomy rates was noted. Further research is warranted, and a prospective study design would facilitate a better causal understanding.</p>}}, author = {{Sajjadi, Saman and Svensson Neufert, Rebecca and Ruhr, Emilia and Tryggmo, Sebastian and Marsal, Jan and Buchwald, Pamela}}, issn = {{0036-5521}}, keywords = {{anti-TNF; biological therapy; colectomy; Inflammatory bowel disease; surgery}}, language = {{eng}}, number = {{1}}, pages = {{15--19}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian Journal of Gastroenterology}}, title = {{Emergency subtotal colectomy rates in relation to anti-TNF therapy in inflammatory bowel disease patients : comparison of retrospective cohorts}}, url = {{http://dx.doi.org/10.1080/00365521.2022.2106151}}, doi = {{10.1080/00365521.2022.2106151}}, volume = {{58}}, year = {{2023}}, }