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Emergency subtotal colectomy rates in relation to anti-TNF therapy in inflammatory bowel disease patients : comparison of retrospective cohorts

Sajjadi, Saman LU ; Svensson Neufert, Rebecca LU orcid ; Ruhr, Emilia ; Tryggmo, Sebastian ; Marsal, Jan LU orcid and Buchwald, Pamela LU (2023) In Scandinavian Journal of Gastroenterology 58(1). p.15-19
Abstract

Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for acute severe colitis at Skåne University Hospital, Sweden, during two six-year windows were included. The two time-windows represented pre- and introductory (2004–2009) versus post-introductory (2012–2017) anti-TNF therapy usage. The two periods were compared in terms of the proportion of patients who received anti-TNF therapy, rates of emergency... (More)

Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for acute severe colitis at Skåne University Hospital, Sweden, during two six-year windows were included. The two time-windows represented pre- and introductory (2004–2009) versus post-introductory (2012–2017) anti-TNF therapy usage. The two periods were compared in terms of the proportion of patients who received anti-TNF therapy, rates of emergency subtotal colectomy, and local IBD prevalence numbers. Results: In total 91 patients were included, 42 (2004–2009) and 49 (2012–2017) patients, respectively. The proportion of patients that received anti-TNF therapy prior to admission was increased from 29% (2004–2009) to 63% (2012–2017) (p =.001). Despite this no significant difference was found in the emergency subtotal colectomy rates between the time periods considering the population at risk (IBD patients living in Skåne county); 1.44/1000 person years versus 1.37/1000 person years (p =.83). Conclusion: Despite an increased proportion of patients with IBD that received anti-TNF therapy prior to admission, no significant decrease in emergency subtotal colectomy rates was noted. Further research is warranted, and a prospective study design would facilitate a better causal understanding.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
anti-TNF, biological therapy, colectomy, Inflammatory bowel disease, surgery
in
Scandinavian Journal of Gastroenterology
volume
58
issue
1
pages
15 - 19
publisher
Taylor & Francis
external identifiers
  • scopus:85135225529
  • pmid:35917586
ISSN
0036-5521
DOI
10.1080/00365521.2022.2106151
language
English
LU publication?
yes
id
46a859f4-a2bc-4cd6-a959-dfc2bdc0477f
date added to LUP
2022-10-06 10:32:23
date last changed
2025-10-19 03:23:59
@article{46a859f4-a2bc-4cd6-a959-dfc2bdc0477f,
  abstract     = {{<p>Objectives: The introduction of anti-TNF therapy has revolutionized the management of inflammatory bowel disease (IBD). This study aimed to investigate the impact of anti-TNF therapy on emergency subtotal colectomy rates in patients with IBD (ulcerative colitis, Crohn’s disease or indeterminate colitis) during two time periods. Methods: IBD patients treated with emergency subtotal colectomy for acute severe colitis at Skåne University Hospital, Sweden, during two six-year windows were included. The two time-windows represented pre- and introductory (2004–2009) versus post-introductory (2012–2017) anti-TNF therapy usage. The two periods were compared in terms of the proportion of patients who received anti-TNF therapy, rates of emergency subtotal colectomy, and local IBD prevalence numbers. Results: In total 91 patients were included, 42 (2004–2009) and 49 (2012–2017) patients, respectively. The proportion of patients that received anti-TNF therapy prior to admission was increased from 29% (2004–2009) to 63% (2012–2017) (p =.001). Despite this no significant difference was found in the emergency subtotal colectomy rates between the time periods considering the population at risk (IBD patients living in Skåne county); 1.44/1000 person years versus 1.37/1000 person years (p =.83). Conclusion: Despite an increased proportion of patients with IBD that received anti-TNF therapy prior to admission, no significant decrease in emergency subtotal colectomy rates was noted. Further research is warranted, and a prospective study design would facilitate a better causal understanding.</p>}},
  author       = {{Sajjadi, Saman and Svensson Neufert, Rebecca and Ruhr, Emilia and Tryggmo, Sebastian and Marsal, Jan and Buchwald, Pamela}},
  issn         = {{0036-5521}},
  keywords     = {{anti-TNF; biological therapy; colectomy; Inflammatory bowel disease; surgery}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{15--19}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Emergency subtotal colectomy rates in relation to anti-TNF therapy in inflammatory bowel disease patients : comparison of retrospective cohorts}},
  url          = {{http://dx.doi.org/10.1080/00365521.2022.2106151}},
  doi          = {{10.1080/00365521.2022.2106151}},
  volume       = {{58}},
  year         = {{2023}},
}