Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease
(2010) In Molecular Neurodegeneration 5.- Abstract
- Alzheimer's disease (AD) is characterized by protein aggregates, i.e. senile plaques and neurofibrillary tangles. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein aggregates. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme with important functions in recycling of ubiquitin. The S18Y polymorphism of the UCHL1 gene confers protection against Parkinson's disease. In this study, the genotype and allele frequencies of the UCHL1 S18Y polymorphism were investigated in 452 AD patients and 234 control subjects, recruited from four memory clinics in Sweden. Using a binary logistic regression model including UCHL1 allele A and APOE epsilon 4 allele positivity, age and sex... (More)
- Alzheimer's disease (AD) is characterized by protein aggregates, i.e. senile plaques and neurofibrillary tangles. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein aggregates. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme with important functions in recycling of ubiquitin. The S18Y polymorphism of the UCHL1 gene confers protection against Parkinson's disease. In this study, the genotype and allele frequencies of the UCHL1 S18Y polymorphism were investigated in 452 AD patients and 234 control subjects, recruited from four memory clinics in Sweden. Using a binary logistic regression model including UCHL1 allele A and APOE epsilon 4 allele positivity, age and sex as covariates with AD diagnosis as dependent variable, an adjusted OR of 0.82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1603676
- author
- Zetterberg, Madeleine ; Sjolander, Annica ; von Otter, Malin ; Palmer, Mona Seibt ; Landgren, Sara ; Minthon, Lennart LU ; Wallin, Anders ; Andreasen, Niels ; Blennow, Kaj and Zetterberg, Henrik
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Neurodegeneration
- volume
- 5
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000276414400001
- scopus:77950591067
- pmid:20302621
- ISSN
- 1750-1326
- DOI
- 10.1186/1750-1326-5-11
- language
- English
- LU publication?
- yes
- id
- 46d30edd-9d1a-4ab3-8787-2b06c0106097 (old id 1603676)
- date added to LUP
- 2016-04-01 14:10:12
- date last changed
- 2022-01-27 23:06:53
@article{46d30edd-9d1a-4ab3-8787-2b06c0106097, abstract = {{Alzheimer's disease (AD) is characterized by protein aggregates, i.e. senile plaques and neurofibrillary tangles. The ubiquitin-proteasome system has been proposed a role in proteolytic removal of these protein aggregates. Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a de-ubiquitinating enzyme with important functions in recycling of ubiquitin. The S18Y polymorphism of the UCHL1 gene confers protection against Parkinson's disease. In this study, the genotype and allele frequencies of the UCHL1 S18Y polymorphism were investigated in 452 AD patients and 234 control subjects, recruited from four memory clinics in Sweden. Using a binary logistic regression model including UCHL1 allele A and APOE epsilon 4 allele positivity, age and sex as covariates with AD diagnosis as dependent variable, an adjusted OR of 0.82 ([95% CI 0.55-1.24], P = 0.35) was obtained for a positive UCHL1 allele A carrier status. The present study thus do not support a protective effect of the UCHL1 S18Y polymorphism against AD.}}, author = {{Zetterberg, Madeleine and Sjolander, Annica and von Otter, Malin and Palmer, Mona Seibt and Landgren, Sara and Minthon, Lennart and Wallin, Anders and Andreasen, Niels and Blennow, Kaj and Zetterberg, Henrik}}, issn = {{1750-1326}}, language = {{eng}}, publisher = {{BioMed Central (BMC)}}, series = {{Molecular Neurodegeneration}}, title = {{Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease}}, url = {{https://lup.lub.lu.se/search/files/3825555/1627887.pdf}}, doi = {{10.1186/1750-1326-5-11}}, volume = {{5}}, year = {{2010}}, }