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Temporal disparity in pineal and retinal ontogeny

Östholm, Thomas ; Ekström, Peter LU ; Bruun, Anita and van Veen, Theo LU (1988) In Developmental Brain Research 42(1). p.1-13
Abstract

The development of photoreceptors and two putative neurotransmitter systems in the pineal organ and retina was studied during embryogenesis in the three-spined stickleback Gasterosteus aculeatus L. The investigation was performed by aid of immunocytochemistry using well characterized antisera to the retinal proteins α-transducin (TDα) and S-antigen (SA) (photoreceptor-markers), antisera against l-glutamic acid decarboxylase (GAD), γ-aminobutyric acid (GABA), choline-O-acetyltransferase (ChAT) and with acetylcholinesterase (AChE) histochemistry (neurotransmitter-markers). It was possible to set up the following developmental time-table concerning the first appearance of positive immuno- and enzyme-reactive cells in the pineal... (More)

The development of photoreceptors and two putative neurotransmitter systems in the pineal organ and retina was studied during embryogenesis in the three-spined stickleback Gasterosteus aculeatus L. The investigation was performed by aid of immunocytochemistry using well characterized antisera to the retinal proteins α-transducin (TDα) and S-antigen (SA) (photoreceptor-markers), antisera against l-glutamic acid decarboxylase (GAD), γ-aminobutyric acid (GABA), choline-O-acetyltransferase (ChAT) and with acetylcholinesterase (AChE) histochemistry (neurotransmitter-markers). It was possible to set up the following developmental time-table concerning the first appearance of positive immuno- and enzyme-reactive cells in the pineal organ and retina: I AChE-activity and TDα- and SA-immunoreactive cells in the pineal organ; II GAD- and GABA-immunoreactive cells in the pineal organ and retina; ChAT immunoreactivity and AChE activity in the retina; III hatching; IV SA-immunoreactive cells in the retina. The obtained results provide good evidence that while photoreceptor cells develop much earlier in the pineal organ than in the retina, neurons develop simultaneously in the pineal organ and retina.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Acetylcholine, Development, Photoreceptor, Pineal organ, Retina, S-antigen, Teleost, α-Transducin, γ-Aminobutyric acid
in
Developmental Brain Research
volume
42
issue
1
pages
13 pages
publisher
Elsevier
external identifiers
  • scopus:0023918261
ISSN
0165-3806
DOI
10.1016/0165-3806(88)90197-6
language
English
LU publication?
no
id
46df669d-78f4-46b0-b9d9-3f006fe4fc7d
date added to LUP
2019-10-03 10:19:41
date last changed
2021-01-03 04:50:24
@article{46df669d-78f4-46b0-b9d9-3f006fe4fc7d,
  abstract     = {{<p>The development of photoreceptors and two putative neurotransmitter systems in the pineal organ and retina was studied during embryogenesis in the three-spined stickleback Gasterosteus aculeatus L. The investigation was performed by aid of immunocytochemistry using well characterized antisera to the retinal proteins α-transducin (TD<sub>α</sub>) and S-antigen (SA) (photoreceptor-markers), antisera against l-glutamic acid decarboxylase (GAD), γ-aminobutyric acid (GABA), choline-O-acetyltransferase (ChAT) and with acetylcholinesterase (AChE) histochemistry (neurotransmitter-markers). It was possible to set up the following developmental time-table concerning the first appearance of positive immuno- and enzyme-reactive cells in the pineal organ and retina: I AChE-activity and TD<sub>α</sub>- and SA-immunoreactive cells in the pineal organ; II GAD- and GABA-immunoreactive cells in the pineal organ and retina; ChAT immunoreactivity and AChE activity in the retina; III hatching; IV SA-immunoreactive cells in the retina. The obtained results provide good evidence that while photoreceptor cells develop much earlier in the pineal organ than in the retina, neurons develop simultaneously in the pineal organ and retina.</p>}},
  author       = {{Östholm, Thomas and Ekström, Peter and Bruun, Anita and van Veen, Theo}},
  issn         = {{0165-3806}},
  keywords     = {{Acetylcholine; Development; Photoreceptor; Pineal organ; Retina; S-antigen; Teleost; α-Transducin; γ-Aminobutyric acid}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  pages        = {{1--13}},
  publisher    = {{Elsevier}},
  series       = {{Developmental Brain Research}},
  title        = {{Temporal disparity in pineal and retinal ontogeny}},
  url          = {{http://dx.doi.org/10.1016/0165-3806(88)90197-6}},
  doi          = {{10.1016/0165-3806(88)90197-6}},
  volume       = {{42}},
  year         = {{1988}},
}