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Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

Barker, Roger A LU ; Parmar, Malin LU ; Kirkeby, Agnete LU ; Björklund, Anders LU ; Thompson, Lachlan LU and Brundin, Patrik LU (2016) In Journal of Parkinson's Disease 6(1). p.57-63
Abstract

Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. With... (More)

Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Parkinson's Disease
volume
6
issue
1
pages
7 pages
publisher
IOS Press
external identifiers
  • wos:000374638600006
  • scopus:84963773053
ISSN
1877-718X
DOI
10.3233/JPD-160798
language
English
LU publication?
yes
id
46f30631-a10c-4c74-878b-29e78391f62f
date added to LUP
2016-04-12 14:30:04
date last changed
2017-04-09 04:44:59
@article{46f30631-a10c-4c74-878b-29e78391f62f,
  abstract     = {<p>Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease.</p>},
  author       = {Barker, Roger A and Parmar, Malin and Kirkeby, Agnete and Björklund, Anders and Thompson, Lachlan and Brundin, Patrik},
  issn         = {1877-718X},
  language     = {eng},
  number       = {1},
  pages        = {57--63},
  publisher    = {IOS Press},
  series       = {Journal of Parkinson's Disease},
  title        = {Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?},
  url          = {http://dx.doi.org/10.3233/JPD-160798},
  volume       = {6},
  year         = {2016},
}