Bacterial glycosidases in pathogenesis and glycoengineering.
Sjögren, Jonathan LU and Collin, Mattias LU
(2014)
In Future Microbiology
9(9).
p.1039-1051
- Abstract
- ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobiology, there is an increased interest in studying the bacterial enzymes that modify the protein glycosylation of their colonized or infected hosts. This is of great importance in order to fully understand bacterial pathogenesis, but it also presents itself as a valuable source for glycoengineering and glycoanalysis tools. This article highlights... (More)
- ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobiology, there is an increased interest in studying the bacterial enzymes that modify the protein glycosylation of their colonized or infected hosts. This is of great importance in order to fully understand bacterial pathogenesis, but it also presents itself as a valuable source for glycoengineering and glycoanalysis tools. This article highlights the role of bacterial glycosidases during infections, introduces the use of such enzymes as glycoengineering tools and discusses the potential of further studies in this emerging field. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4733317
- author
- Sjögren, Jonathan
LU
and Collin, Mattias
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Future Microbiology
- volume
- 9
- issue
- 9
- pages
- 1039 - 1051
- publisher
- Future Medicine Ltd.
- external identifiers
-
- pmid:25340834
- wos:000344177500004
- scopus:84908148687
- ISSN
- 1746-0921
- DOI
- 10.2217/fmb.14.71
- language
- English
- LU publication?
- yes
- id
- 3e3003f4-8afe-4b81-b385-0428ce1d2125 (old id 4733317)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25340834?dopt=Abstract
- date added to LUP
- 2016-04-01 10:17:06
- date last changed
- 2022-11-24 08:18:57
@article{3e3003f4-8afe-4b81-b385-0428ce1d2125,
abstract = {{ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobiology, there is an increased interest in studying the bacterial enzymes that modify the protein glycosylation of their colonized or infected hosts. This is of great importance in order to fully understand bacterial pathogenesis, but it also presents itself as a valuable source for glycoengineering and glycoanalysis tools. This article highlights the role of bacterial glycosidases during infections, introduces the use of such enzymes as glycoengineering tools and discusses the potential of further studies in this emerging field.}},
author = {{Sjögren, Jonathan and Collin, Mattias}},
issn = {{1746-0921}},
language = {{eng}},
number = {{9}},
pages = {{1039--1051}},
publisher = {{Future Medicine Ltd.}},
series = {{Future Microbiology}},
title = {{Bacterial glycosidases in pathogenesis and glycoengineering.}},
url = {{http://dx.doi.org/10.2217/fmb.14.71}},
doi = {{10.2217/fmb.14.71}},
volume = {{9}},
year = {{2014}},
}