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Bacterial glycosidases in pathogenesis and glycoengineering.

Sjögren, Jonathan LU and Collin, Mattias LU (2014) In Future Microbiology 9(9). p.1039-1051
Abstract
ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobiology, there is an increased interest in studying the bacterial enzymes that modify the protein glycosylation of their colonized or infected hosts. This is of great importance in order to fully understand bacterial pathogenesis, but it also presents itself as a valuable source for glycoengineering and glycoanalysis tools. This article highlights... (More)
ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobiology, there is an increased interest in studying the bacterial enzymes that modify the protein glycosylation of their colonized or infected hosts. This is of great importance in order to fully understand bacterial pathogenesis, but it also presents itself as a valuable source for glycoengineering and glycoanalysis tools. This article highlights the role of bacterial glycosidases during infections, introduces the use of such enzymes as glycoengineering tools and discusses the potential of further studies in this emerging field. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Future Microbiology
volume
9
issue
9
pages
1039 - 1051
publisher
Future Medicine Ltd.
external identifiers
  • pmid:25340834
  • wos:000344177500004
  • scopus:84908148687
ISSN
1746-0921
DOI
10.2217/fmb.14.71
language
English
LU publication?
yes
id
3e3003f4-8afe-4b81-b385-0428ce1d2125 (old id 4733317)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25340834?dopt=Abstract
date added to LUP
2014-11-10 17:57:55
date last changed
2017-07-19 14:45:10
@article{3e3003f4-8afe-4b81-b385-0428ce1d2125,
  abstract     = {ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobiology, there is an increased interest in studying the bacterial enzymes that modify the protein glycosylation of their colonized or infected hosts. This is of great importance in order to fully understand bacterial pathogenesis, but it also presents itself as a valuable source for glycoengineering and glycoanalysis tools. This article highlights the role of bacterial glycosidases during infections, introduces the use of such enzymes as glycoengineering tools and discusses the potential of further studies in this emerging field.},
  author       = {Sjögren, Jonathan and Collin, Mattias},
  issn         = {1746-0921},
  language     = {eng},
  number       = {9},
  pages        = {1039--1051},
  publisher    = {Future Medicine Ltd.},
  series       = {Future Microbiology},
  title        = {Bacterial glycosidases in pathogenesis and glycoengineering.},
  url          = {http://dx.doi.org/10.2217/fmb.14.71},
  volume       = {9},
  year         = {2014},
}