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Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings.

Brodszki, Nicholas LU ; Jönsson, Göran LU ; Melander Skattum, Lillemor LU and Truedsson, Lennart LU (2014) In BMC Immunology 15(1).
Abstract
Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement... (More)
Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement of immunoglobulins (IgG, IgA, IgM, IgE and IgG subclasses), and assessment of the complement system (classical, alternative and lectin pathways). In addition, results of these immunological analyses in other children from the same area and time period were evaluated. (Less)
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author
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published
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in
BMC Immunology
volume
15
issue
1
publisher
BioMed Central
external identifiers
  • pmid:25318568
  • wos:000341523200001
  • scopus:84906927357
ISSN
1471-2172
DOI
10.1186/s12865-014-0031-6
language
English
LU publication?
yes
id
73f757f1-8089-4fa3-bc2f-40c0cdccde57 (old id 4736875)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25318568?dopt=Abstract
date added to LUP
2014-11-09 21:17:54
date last changed
2017-05-21 04:13:16
@article{73f757f1-8089-4fa3-bc2f-40c0cdccde57,
  abstract     = {Primary immunodeficiency diseases (PIDs) comprise a heterogeneous group of disorders mainly characterized by increased susceptibility to infections. The aims of this study were to estimate the occurrence rate of PID in the paediatric (age ≤ 18 years) population of southern Sweden (approx. 265,000 children) and to describe their demographic, clinical and immunological characteristics. During a period of 4 years, in four paediatric speciality clinics in Skåne County in southern Sweden, children being seen for infections and fulfilling specific criteria were evaluated according to a predefined examination schedule. The initial analysis consisted of complete blood counts with analysis of lymphocyte subpopulations (T, B, NK cells), measurement of immunoglobulins (IgG, IgA, IgM, IgE and IgG subclasses), and assessment of the complement system (classical, alternative and lectin pathways). In addition, results of these immunological analyses in other children from the same area and time period were evaluated.},
  articleno    = {31},
  author       = {Brodszki, Nicholas and Jönsson, Göran and Melander Skattum, Lillemor and Truedsson, Lennart},
  issn         = {1471-2172},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {BMC Immunology},
  title        = {Primary immunodeficiency in infection-prone children in southern Sweden: occurrence, clinical characteristics and immunological findings.},
  url          = {http://dx.doi.org/10.1186/s12865-014-0031-6},
  volume       = {15},
  year         = {2014},
}